Microglia Development and Function

被引：835

作者：

Nayak, Debasis ^{[1
]}

Roth, Theodore L. ^{[1
]}

McGavern, Dorian B. ^{[1
]}

机构：

[1] NINDS, NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 | 2014年 / 32卷

关键词：

brain; innate immunity; myeloid cells; two-photon; CENTRAL-NERVOUS-SYSTEM; COLONY-STIMULATING FACTOR-1; MOUSE MODEL; TOXOPLASMA-GONDII; MYELOID CELLS; GROWTH-FACTOR; BACTERIAL-MENINGITIS; TRANSCRIPTION FACTOR; INTERFERON-GAMMA; CEREBRAL MALARIA;

D O I：

10.1146/annurev-immunol-032713-120240

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Proper development and function of the mammalian central nervous system (CNS) depend critically on the activity of parenchymal sentinels referred to as microglia. Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded considerably upon this narrow view and ascribed many functions to these dynamic CNS inhabitants. Microglia are now considered among the most versatile cells in the body, possessing the capacity to morphologically and functionally adapt to their ever-changing surroundings. Even in a resting state, the processes of microglia are highly dynamic and perpetually scan the CNS. Microglia are in fact vital participants in CNS homeostasis, and dysregulation of these sentinels can give rise to neurological disease. In this review, we discuss the exciting developments in our understanding of microglial biology, from their developmental origin to their participation in CNS homeostasis and pathophysiological states such as neuropsychiatric disorders, neurodegeneration, sterile injury responses, and infectious diseases. We also delve into the world of microglial dynamics recently uncovered using real-time imaging techniques.

引用

页码：367 / 402

页数：36

共 221 条

[41] Neutralization of macrophage inflammatory protein 2 (MIP-2) and MIP-1α attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis [J].