C-Reactive Protein/Albumin Ratio (CAR) as a Prognostic Factor in Patients with Non-Metastatic Nasopharyngeal Carcinoma

被引：21
作者：
He, ShaSha [1 ,2 ,3 ]
Wang, Yan [1 ,2 ,3 ]
Chen, HaiYang [4 ]
Yang, Lin [1 ,2 ,3 ]
Liang, ShaoBo [5 ]
Lu, Lixia [1 ,2 ,3 ]
Chen, Yong [1 ,2 ,3 ]
机构：
[1] Sun Yat Sen Univ, Ctr Canc, 651 Dongfeng Rd East, Guangzhou, Guangdong, Peoples R China
[2] State Key Lab Oncol Southern China, Guangzhou, Guangdong, Peoples R China
[3] Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 6, Guangzhou, Guangdong, Peoples R China
[5] First Hosp Foshan, Foshan, Peoples R China
来源：
JOURNAL OF CANCER | 2016年 / 7卷 / 15期
关键词：
Nasopharyngeal carcinoma; C-reactive protein; albumin; Epstein-Barr virus DNA; prognosis; BARR-VIRUS DNA; LYMPHOCYTE RATIOS; CANCER; SURVIVAL; PROTEIN; CELL; INFLAMMATION; NEUTROPHIL; PLASMA; HYPOALBUMINEMIA;
D O I：
10.7150/jca.16443
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The C-reactive protein/albumin (CRP/ALB) ratio has recently been associated with clinical outcomes in patients suffering various types of cancer. In this retrospective study, we investigated the prognostic value of the pre-treatment CRP/ALB ratio (CAR) in non-metastatic nasopharyngeal carcinoma (NPC) patients. Methods: The cohort included 2685 patients with non-metastatic NPC. Univariate and multivariate COX proportional hazards analyses were applied to evaluate the associations of CAR with overall survival (OS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and locoregional recurrence-free survival (LRRFS) in patients with NPC. Kaplan-Meier survival analyses was used to compare groups classified by CAR. Results: Patients were categorised by the CAR using a cut-off value of 0.064. Multivariate Cox proportional hazard analysis verified that high CAR level was a significant predictor for inferior OS (P = 0.003), DMFS (P = 0.035), and LRRFS (P = 0.024), but not for DFS (P = 0.093). CAR was also an independent prognostic factor for OS when stratified by Epstein-Barr virus DNA level (>= 2560 or < 2560 copies ml(-1)). Conclusions: High CAR provides prognostication regarding OS, DMFS, DFS, and LRRFS in patients with NPC. CAR is a valuable coadjutant for Epstein-Barr virus DNA levels for identifying survival differences.
引用
收藏
页码：2360 / 2366
页数：7
相关论文
共 32 条
[1]   C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study [J].
Al-Subaie, N. ;
Reynolds, T. ;
Myers, A. ;
Sunderland, R. ;
Rhodes, A. ;
Grounds, R. M. ;
Hall, G. M. .
BRITISH JOURNAL OF ANAESTHESIA, 2010, 105 (03) :318-325
[2]   Plasma Epstein-Barr Virus DNA Level Strongly Predicts Survival in Metastatic/Recurrent Nasopharyngeal Carcinoma Treated With Palliative Chemotherapy [J].
An, Xin ;
Wang, Feng-Hua ;
Ding, Pei-Rong ;
Deng, Ling ;
Jiang, Wen-Qi ;
Zhang, Li ;
Shao, Jian-Yong ;
Li, Yu-Hong .
CANCER, 2011, 117 (16) :3750-3757
[3]   Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma [J].
Andersson, Bengt-Ake ;
Lewin, Freddi ;
Lundgren, Jan ;
Nilsson, Mats ;
Rutqvist, Lars-Erik ;
Lofgren, Sture ;
Laytragoon-Lewin, Nongnit .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2014, 140 (03) :515-519
[4]   Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios as Prognostic Factors after Stereotactic Radiation Therapy for Early-Stage Non-Small-Cell Lung Cancer [J].
Cannon, Nathan A. ;
Meyer, Jeffrey ;
Iyengar, Puneeth ;
Ahn, Chul ;
Westover, Kenneth D. ;
Choy, Hak ;
Timmerman, Robert .
JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (02) :280-285
[5]   Nasopharyngeal carcinoma [J].
Chan, ATC ;
Teo, PML ;
Johnson, PJ .
ANNALS OF ONCOLOGY, 2002, 13 (07) :1007-1015
[6]   Haemoglobin, Neutrophil to Lymphocyte Ratio and Platelet Count Improve Prognosis Prediction of the TNM Staging System in Nasopharyngeal Carcinoma: Development and Validation in 3237 Patients from a Single Institution [J].
Chang, H. ;
Gao, J. ;
Xu, B. Q. ;
Guo, S. P. ;
Lu, R. B. ;
Li, G. ;
Huang, S. M. ;
Han, F. ;
Liu, Z. G. ;
Tao, Y. L. ;
Tu, Z. W. ;
Chen, C. ;
Li, X. H. ;
Xia, Y. F. .
CLINICAL ONCOLOGY, 2013, 25 (11) :639-646
[7]   Comparison of Intensity-Modulated Radiotherapy Using Helical Tomotherapy and Segmental Multileaf Collimator-based Techniques for Nasopharyngeal Carcinoma: Dosimetric Analysis Incorporating Quality Assurance Guidelines from RTOG 0225 [J].
Chen, Allen M. ;
Lee, Nancy Y. ;
Yang, Claus C. ;
Liu, Tianxiao ;
Narayan, Samir ;
Vijayakumar, Srinivasan ;
Purdy, James A. .
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2010, 9 (03) :291-298
[8]   Prognostic Value of Plasma Epstein-Barr Virus DNA for Local and Regionally Advanced Nasopharyngeal Carcinoma Treated With Cisplatin-Based Concurrent Chemoradiotherapy in Intensity-Modulated Radiotherapy Era [J].
Chen, Wen-Hui ;
Tang, Lin-Quan ;
Guo, Shan-Shan ;
Chen, Qiu-Yan ;
Zhang, Lu ;
Liu, Li-Ting ;
Qian, Chao-Nan ;
Guo, Xiang ;
Xie, Dan ;
Zeng, Mu-Sheng ;
Mai, Hai-Qiang .
MEDICINE, 2016, 95 (05)
[9]   Nasopharyngeal carcinoma [J].
Chua, Melvin L. K. ;
Wee, Joseph T. S. ;
Hui, Edwin P. ;
Chan, Anthony T. C. .
LANCET, 2016, 387 (10022) :1012-1024
[10]   Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability [J].
Colotta, Francesco ;
Allavena, Paola ;
Sica, Antonio ;
Garlanda, Cecilia ;
Mantovani, Alberto .
CARCINOGENESIS, 2009, 30 (07) :1073-1081
1234