HOW HYDROGEN BONDS SHAPE MEMBRANE PROTEIN STRUCTURE

被引:31
|
作者
White, Stephen H. [1 ]
机构
[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA
来源
关键词
D O I
10.1016/S0065-3233(05)72006-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The energetic cost of partitioning peptide bonds into membrane bi-layers is prohibitive unless the peptide bonds participate in hydrogen bonds. However, even then there is a significant free energy penalty for dehydrating the peptide bonds that can only be overcome by favorable hydrophobic interactions. Membrane protein structure formation is thus dominated by hydrogen bonding interactions, which is the subject of this review.
引用
收藏
页码:157 / 172
页数:16
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