Evidence for addiction-like behavior in the rat

被引：816

作者：

Deroche-Gamonet, V ^{[1
]}

Belin, D ^{[1
]}

Piazza, PV ^{[1
]}

机构：

[1] Univ Victor Segalen Bordeaux 2, Bordeaux Inst Neurosci, Lab Physiopathol Comportements, INSERM U588, F-33077 Bordeaux, France

来源：

SCIENCE | 2004年 / 305卷 / 5686期

关键词：

D O I：

10.1126/science.1099020

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although the voluntary intake of drugs of abuse is a behavior largely preserved throughout phylogeny, it is currently unclear whether pathological drug use ("addiction") can be observed in species other than humans. Here, we report that behaviors that resemble three of the essential diagnostic criteria for addiction appear over time in rats trained to self-administer cocaine. As in humans, this addiction-like behavior is present only in a small proportion of subjects using cocaine and is highly predictive of relapse after withdrawal. These findings provide a new basis for developing a true understanding and treatment of addiction.

引用

页码：1014 / 1017

页数：4

共 29 条

[1] The development of an ethanol model using social insects I:: Behavior studies of the honey bee (Apis mellifera L.) [J].