Synthesis and biological activity of novel 4-/5-/6-/7-nitro-N′-(4-aryl-1,3-thiazol-2-yl)-1H-indole-2-carbohydrazide derivatives

被引：5
|
作者：
Ashalatha, B. V.
Narayana, B. [1 ]
Kumari, N. Suchetha
机构：
[1] Mangalore Univ, Dept Postgrad Studies & Res Chem, Mangalagangothri 574199, India
[2] KS Hegde Med Acad, Dept Biochem, Deralakatte, India
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2006年 / 181卷 / 12期
关键词：
1H-indole; 1,3-thiazole; biological activity; nitro; synthesis;
D O I：
10.1080/10426500600864684
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
New 4-/5-/6-/7-nitro-N'-(4-aryl-1,3-thiazol-2-yl)-1H-indole-2-carbohydrazides (4a-t) were prepared by treating respective nitroindole thiosemicarbazide with aromatic acylbromides. The newly synthesized compounds were characterized by analytical and spectral data. The compounds were also screened for antifungal and antibacterial activity. Some of the compounds exhibited promising antimicrobial activity.
引用
收藏
页码：2785 / 2795
页数：11
相关论文
共 50 条
  • [1] Synthesis of some bioactive 2-bromo-5-methoxy-N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives
    Raj, K. K. Vijaya
    Narayana, B.
    Ashalatha, B. V.
    Kumari, N. Suchetha
    Sarojini, B. K.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (03) : 425 - 429
  • [2] Synthesis of 5-amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)2,3-dihydro-1H-pyrrol-3-ones
    Volovenko, YM
    Volovnenko, TA
    Tverdokhlebov, AV
    Ryabokon, IG
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2001, 37 (09) : 1323 - 1329
  • [3] Synthesis of 5-Amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)- 2,3-dihydro-1H-pyrrol-3-ones*
    Yu. M. Volovenko
    T. A. Volovnenko
    A. V. Tverdokhlebov
    I. G. Ryabokon'
    Russian Journal of Organic Chemistry, 2001, 37 : 1323 - 1329
  • [4] Synthesis and Antimicrobial Screening of New 5-Aryl-3-(4-Aryl-1,3-Thiazol-2-yl)-1,2-Oxazole Derivatives
    Bhoye, Manish R.
    Shinde, Abhijit
    Mahadik, Neha
    Mhaske, Pravin C.
    POLYCYCLIC AROMATIC COMPOUNDS, 2025,
  • [5] Synthesis and molecular structure of 1-(pyrimidin-2-yl)-2-(4-aryl-1,3-thiazol-2-yl)hydrazines
    Erkin, A. V.
    Krutikov, V. I.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2011, 81 (08) : 1699 - 1704
  • [6] Synthesis and molecular structure of 1-(pyrimidin-2-yl)-2-(4-aryl-1,3-thiazol-2-yl)hydrazines
    A. V. Erkin
    V. I. Krutikov
    Russian Journal of General Chemistry, 2011, 81 : 1699 - 1704
  • [7] Synthesis of 3-[4-(1-Benzofuran-2-yl)-1,3-thiazol-2-yl]-2-(4-aryl)-1,3-thiazolidin-4-one Derivatives as Biological Agents
    Venkatesh, Bhovi K.
    Bodke, Yadav D.
    Biradar, S. A.
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2010, 185 (09) : 1926 - 1931
  • [8] Synthesis of 1H-1,2,3-triazole derivatives by the cyclization of aryl azides with 2-benzothiazolylacetonone, 1,3-benzo-thiazol-2-ylacetonitrile, and (4-aryl-1,3-thiazol-2-yl)acetonitriles
    N. T. Pokhodylo
    V. S. Matiychuk
    N. B. Obushak
    Chemistry of Heterocyclic Compounds, 2009, 45 : 483 - 488
  • [9] Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts
    Gein, V. L.
    Bobrovskaya, O. V.
    Russkikh, A. A.
    Novikova, V. V.
    Gein, O. N.
    Karpenko, Yu. N.
    Chashchina, S. V.
    Dmitriev, M. V.
    Yankin, A. N.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (04) : 680 - 688
  • [10] Synthesis of 1H-1,2,3-triazole derivatives by the cyclization of aryl azides with 2-benzothiazolylacetonone, 1,3-benzo-thiazol-2-ylacetonitrile, and (4-aryl-1,3-thiazol-2-yl)acetonitriles
    Pokhodylo, N. T.
    Matiychuk, V. S.
    Obushak, N. B.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (04) : 483 - 488
12345