Viruses and RNA Interference: Issues and Controversies

被引：34

作者：

Cullen, Bryan R. ^{[1
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机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27708 USA

[2] Duke Univ, Med Ctr, Ctr Virol, Durham, NC USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 22期

关键词：

DOUBLE-STRANDED-RNA; MOUSE OOCYTES; GENE-EXPRESSION; HUMAN DICER; CELLS; SIRNAS; DSRNAS;

D O I：

10.1128/JVI.01179-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The question of whether any mammalian cells are able to mount an effective RNA interference-mediated antiviral innate immune response has remained highly controversial. In this Gem, I review recent data addressing this important issue and propose a testable hypothesis that can explain many of the apparently contradictory results published in this area of research.

引用

页码：12934 / 12936

页数：3

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