Classification of osteoarthritis biomarkers:: a proposed approach

被引：293

作者：

Bauer, D. C.

Hunter, D. J.

Abramson, S. B.

Attur, M.

Corr, M.

Felson, D.

Heinegard, D.

Jordan, J. M.

Kepler, T. B.

Lane, N. E.

Saxne, T.

Tyree, B.

Kraus, V. B.

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94107 USA

[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94107 USA

[3] Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USA

[4] NYU, Sch Med, Dept Med, New York, NY USA

[5] NYU, Hosp Joint Dis, New York, NY USA

[6] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[7] Lund Univ, Dept Expt Med Sci, Lund, Sweden

[8] Univ N Carolina, Dept Med, Chapel Hill, NC USA

[9] Univ N Carolina, Dept Orthoped, Chapel Hill, NC USA

[10] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[11] Univ Calif Davis, Dept Med, Sacramento, CA 95817 USA

[12] Lund Univ, Dept Clin Sci, Lund, Sweden

[13] NIAMSD, Extramural Program, Bethesda, MD 20892 USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2006年 / 14卷 / 08期

基金：

美国国家卫生研究院;

关键词：

osteoarthritis; biomarkers; study design;

D O I：

10.1016/j.joca.2006.04.001

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for CA are developed and tested in clinical studies, biomarkers; that reliably mirror or predict the progression or amelioration of CA will also be needed. Methods: The NIH-funded CA Biomarkers Network is a multidisciplinary group interested in the development and validation of CA biomarkers. This review summarizes our efforts to characterize and classify CA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in CA investigations. Conclusion. The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：723 / 727

页数：5

共 23 条

[1] DEVELOPMENT OF CRITERIA FOR THE CLASSIFICATION AND REPORTING OF OSTEOARTHRITIS - CLASSIFICATION OF OSTEOARTHRITIS OF THE KNEE [J].

ALTMAN, R ;

ASCH, E ;

BLOCH, D ;

BOLE, G ;

BORENSTEIN, D ;

BRANDT, K ;

CHRISTY, W ;

COOKE, TD ;

GREENWALD, R ;

HOCHBERG, M ;

HOWELL, D ;

KAPLAN, D ;

KOOPMAN, W ;

LONGLEY, S ;

MANKIN, H ;

MCSHANE, DJ ;

MEDSGER, T ;

MEENAN, R ;

MIKKELSEN, W ;

MOSKOWITZ, R ;

MURPHY, W ;

ROTHSCHILD, B ;

SEGAL, M ;

SOKOLOFF, L ;

WOLFE, F .

ARTHRITIS AND RHEUMATISM, 1986, 29 (08) :1039-1049

[2]

Clark AG, 1999, ARTHRITIS RHEUM, V42, P2356, DOI 10.1002/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO

[3]

2-R

[4] Osteoarthritis pain and its treatment [J].

Creamer, P .

CURRENT OPINION IN RHEUMATOLOGY, 2000, 12 (05) :450-455

[5] Considerations in the evaluation of surrogate endpoints in clinical trials: Summary of a National Institutes of Health Workshop [J].

De Gruttola, VG ;

Clax, P ;

DeMets, DL ;

Downing, GJ ;

Ellenberg, SS ;

Friedman, L ;

Gail, MH ;

Prentice, R ;

Wittes, J ;

Zeger, SL .

CONTROLLED CLINICAL TRIALS, 2001, 22 (05) :485-502

[6] Pathogenesis and management of pain in osteoarthritis [J].

Dieppe, PA ;

Lohmander, LS .

LANCET, 2005, 365 (9463) :965-973

[7] Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project [J].

Elliott, AL ;

Kraus, VB ;

Luta, G ;

Stabler, T ;

Renner, JB ;

Woodard, J ;

Dragomir, AD ;

Helmick, CG ;

Hochberg, MC ;

Jordan, JM .

ARTHRITIS AND RHEUMATISM, 2005, 52 (01) :105-111

[8] STATISTICAL VALIDATION OF INTERMEDIATE END-POINTS FOR CHRONIC DISEASES [J].

FREEDMAN, LS ;

GRAUBARD, BI ;

SCHATZKIN, A .

STATISTICS IN MEDICINE, 1992, 11 (02) :167-178

[9] Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis - A three-month longitudinal study [J].

Garnero, P ;

Peterfy, C ;

Zaim, S ;

Schoenharting, M .

ARTHRITIS AND RHEUMATISM, 2005, 52 (09) :2822-2829

[10] Association between spine disc degeneration and type II collagen degradation in postmenopausal women - The OFELY Study [J].

Garnero, P ;

Sornay-Rendu, E ;

Arlot, M ;

Christiansen, C ;

Delmas, PD .

ARTHRITIS AND RHEUMATISM, 2004, 50 (10) :3137-3144

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