Rapid Molecular Detection of Inducible Macrolide Resistance in Mycobacterium chelonae and M-abscessus Strains: a Replacement for 14-Day Susceptibility Testing?

被引:23
作者
Hanson, Kimberly E. [1 ,2 ]
Slechta, E. Susan [3 ]
Muir, Haleina [4 ]
Barker, Adam P. [2 ,3 ]
机构
[1] Univ Utah, Dept Med, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Pathol, Salt Lake City, UT USA
[3] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA
[4] ARUP Special Microbiol Lab, Salt Lake City, UT USA
关键词
CLARITHROMYCIN; MASSILIENSE; DIFFERENTIATION; GENE;
D O I
10.1128/JCM.03464-13
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The erm(41) gene causes inducible macrolide resistance in Mycobacterium abscessus but not Mycobacterium chelonae. erm(41) sequencing of 285 M. abscessus and 45 M. chelonae isolates was compared to 14-day susceptibility; agreement percentages were 98.9% and 100%, respectively. Extended incubation may not be necessary for M. chelonae, and the erm(41) genotype is a useful adjunct for M. abscessus.
引用
收藏
页码:1705 / 1707
页数:3
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