Impact of insulin resistance on the developmental potential of immature oocytes retrieved from human chorionic gonadotropin-primed women with polycystic ovary syndrome undergoing in vitro maturation

被引：21

作者：

Vlaisavljevic, Veljko ^{[1
]}

Kovac, Vilma ^{[1
]}

Cizek, Mojca ^{[1
]}

机构：

[1] Maribor Teaching Hosp, Dept Reprod Med & Gynecol Endocirnol, Maribor 2000, Slovenia

来源：

FERTILITY AND STERILITY | 2009年 / 91卷 / 03期

关键词：

OVULATION INDUCTION; METFORMIN; QUALITY; PCOS; IVF;

D O I：

10.1016/j.fertnstert.2007.12.062

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In a homeostasis model assessment-insulin resistance (HOMA-IR)-positive group of women with polycystic ovary syndrome undergoing in vitro maturation (IVM), the maturation rate of immature oocytes was significantly lower compared with a HOMA-IR negative group of women (47% vs. 59%). The results of our study showed that IR and hyperinsulinemia have an adverse effect on the developmental potential of immature oocytes retrieved in the IVM procedure. (Fertil Steril (R) 2009;91:957-9. (c) 2009 by American Society for Reproductive Medicine.)

引用

页码：957 / 959

页数：3

共 16 条

[1] Oocyte quality in polycystic ovaries revisited: Identification of a particular subgroup of women [J].

Cano, F ;

GarciaVelasco, JA ;

Millet, A ;

Remohi, J ;

Simon, C ;

Pellicer, A .

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1997, 14 (05) :254-261

[2] State of the art in in-vitro oocyte maturation [J].

Chian, RC ;

Lim, JH ;

Tan, SL .

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2004, 16 (03) :211-219

[3] The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome [J].

Dale, PO ;

Tanbo, T ;

Haug, E ;

Åbyholm, T .

HUMAN REPRODUCTION, 1998, 13 (03) :567-570

[4]

EPPIG JJ, 2003, BIOL PATHOLOGY OOCYT

[5] Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) [J].

Fauser, BCJM ;

Chang, J ;

Azziz, R ;

Legro, R ;

Dewailly, D ;

Franks, S ;

Tarlatzis, BC ;

Fauser, B ;

Balen, A ;

Bouchard, P ;

Dahlgren, E ;

Devoto, L ;

Diamanti, E ;

Dunaif, A ;

Filicori, M ;

Homburg, R ;

Ibanez, L ;

Laven, J ;

Magoffin, D ;

Nestler, J ;

Norman, RJ ;

Pasquali, R ;

Pugeat, M ;

Strauss, J ;

Tan, S ;

Taylor, A ;

Wild, R ;

Wild, S ;

Ehrmann, D ;

Lobo, R .

HUMAN REPRODUCTION, 2004, 19 (01) :41-47

[6] The impact of obesity and insulin resistance on the outcome of IVF or ICSI in women with polycystic ovarian syndrome [J].

Fedorcsák, P ;

Dale, PO ;

Storeng, R ;

Tanbo, T ;

Åbyholm, T .

HUMAN REPRODUCTION, 2001, 16 (06) :1086-1091

[7]

Franks S, 2002, REPROD BIOMED ONLINE, V6, P181

[8] Should patients with polycystic ovarian syndrome be treated with metformin? A note of cautious optimism [J].

Homburg, R .

HUMAN REPRODUCTION, 2002, 17 (04) :853-856

[9] A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome [J].

Legro, RS ;

Finegood, D ;

Dunaif, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (08) :2694-2698

[10] Benefit of FSH priming of women with PCOS to the in vitro maturation procedure and the outcome:: a randomized prospective study [J].

Mikkelsen, AL ;

Lindenberg, S .

REPRODUCTION, 2001, 122 (04) :587-592

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