Ce(OTf)3-Catalyzed [3+2] Cycloaddition of Azides with Nitroolefins: Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles

被引：127

作者：

Wang, Ying-Chun ^{[1
,2
]}

Xie, Yu-Yang ^{[1
]}

Qu, Hong-En ^{[1
]}

Wang, Heng-Shan ^{[1
]}

Pan, Ying-Ming ^{[1
]}

Huang, Fu-Ping ^{[1
]}

机构：

[1] Guangxi Normal Univ, Sch Chem & Chem Engn, Minist Educ China, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[2] Jishou Univ, Coll Chem & Chem Engn, Jishou 416000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 10期

基金：

中国国家自然科学基金;

关键词：

RUTHENIUM-CATALYZED CYCLOADDITION; CLICK CHEMISTRY; ALKYNES; SCOPE;

D O I：

10.1021/jo5004339

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of rare earth metal-catalyzed [3 + 2] cycloaddition of organic azides with nitroolefins and subsequent elimination reaction is described. In the presence of a catalytic amount of Ce(OTf)(3), both benzyl and phenyl azides react with a broad range of aryl nitroolefins containing a range of functionalities selectively producing 1,5-disubstituted 1,2,3-triazoles in good to excellent yields.

引用

页码：4463 / 4469

页数：7

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