Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat

被引：118

作者：

Zepeda Mendoza, M. Lisandra ^{[1
]}

Xiong, Zijun ^{[2
,3
]}

Escalera-Zamudio, Marina ^{[4
]}

Runge, Anne Kathrine ^{[1
]}

Theze, Julien ^{[5
]}

Streicker, Daniel ^{[6
,7
]}

Frank, Hannah K. ^{[8
]}

Loza-Rubio, Elizabeth ^{[9
]}

Liu, Shengmao ^{[3
]}

Ryder, Oliver A. ^{[10
]}

Castruita, Jose Alfredo Samaniego ^{[1
]}

Katzourakis, Aris ^{[5
]}

Pacheco, George ^{[1
]}

Taboada, Blanca ^{[11
]}

Loeber, Ulrike ^{[4
]}

Pybus, Oliver G. ^{[5
]}

Li, Yang ^{[3
]}

Rojas-Anaya, Edith ^{[9
]}

Bohmann, Kristine ^{[1
]}

Carmona Baez, Aldo ^{[1
,12
]}

Arias, Carlos F. ^{[11
]}

Liu, Shiping ^{[3
]}

Greenwood, Alex D. ^{[4
,13
]}

Bertelsen, Mads F. ^{[14
]}

White, Nicole E. ^{[15
,16
]}

Bunce, Michael ^{[15
,16
]}

Zhang, Guojie ^{[2
,3
,17
]}

Sicheritz-Ponten, Thomas ^{[18
]}

Gilbert, M. P. Thomas ^{[1
,16
,19
]}

机构：

[1] Univ Copenhagen, Ctr GeoGenet, Nat Hist Museum Denmark, Copenhagen, Denmark

[2] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China

[3] China BGI Shenzhen, Natl GeneBank, Shenzhen, Peoples R China

[4] Leibniz Inst Zoo & Wildlife Res IZW, Dept Wildlife Dis, Berlin, Germany

[5] Univ Oxford, Dept Zool, Oxford, England

[6] Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Glasgow, Lanark, Scotland

[7] Univ Glasgow, MRC Univ Glasgow Ctr Virus Res, Glasgow, Lanark, Scotland

[8] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[9] Ctr Nacl Invest Disciplinaria Microbiol Anim INIF, Ciudad De Mexico, Mexico

[10] San Diego Zoo Inst Conservat Res, Escondido, CA USA

[11] Univ Nacl Autonoma Mexico, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca, Morelos, Mexico

[12] Univ Nacl Autonoma Mexico, Undergrad Program Genom Sci, Ctr Genom Sci, Cuernavaca, Morelos, Mexico

[13] Free Univ Berlin, Dept Vet Med, Berlin, Germany

[14] Copenhagen Zoo, Ctr Zoo & Wild Anim Hlth, Frederiksberg, Denmark

[15] Curtin Univ, Australian Wildlife Forens Serv, Dept Environm & Agr, Perth, WA, Australia

[16] Curtin Univ, Dept Environm & Agr, Trace & Environm DNA Lab, Perth, WA, Australia

[17] Univ Copenhagen, Dept Biol, Ctr Social Evolut, Copenhagen, Denmark

[18] Tech Univ Denmark, Dept Bio & Hlth Informat, Ctr Biol Sequence Anal, Lyngby, Denmark

[19] Norwegian Univ Sci & Technol, Univ Museum, Trondheim, Norway

来源：

NATURE ECOLOGY & EVOLUTION | 2018年 / 2卷 / 04期

基金：

美国国家科学基金会; 欧洲研究理事会; 新加坡国家研究基金会; 英国惠康基金;

关键词：

MULTIPLE SEQUENCE ALIGNMENT; GUT MICROBIOTA; HIRUDO-MEDICINALIS; DESMODUS-ROTUNDUS; CRYSTAL-STRUCTURE; DIGESTIVE-TRACT; REVEALS; BLOOD; TOOL; METABOLISM;

D O I：

10.1038/s41559-018-0476-8

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.

引用

页码：659 / 668

页数：10

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