Inhibitory and activating functions for MAPK Kss1 in the S-cerevisiae filamentous-growth signalling pathway

被引：225

作者：

Cook, JG ^{[1
]}

Bardwell, L ^{[1
]}

Thorner, J ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DEPT MOL & CELL BIOL, DIV BIOCHEM & MOL BIOL, BERKELEY, CA 94720 USA

来源：

NATURE | 1997年 / 390卷 / 6655期

关键词：

D O I：

10.1038/36355

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mitogen-activated protein kinase (MAPK) cascades are conserved signalling modules that regulate responses to diverse extracellular stimuli, developmental cues and environmental stresses (reviewed in refs 1-3). A MAPK is phosphorylated and activated by a MAPK kinase (MAPKK), which is activated by an upstream protein kinase, such as Raf, Mos or a MAPKK kinase. Ste7, a MAPKK in the yeast Saccharomyces cerevisiae, is required for two developmental pathways: mating(4) and invasive (filamentous) growth(5,6). Kss1 and Fus3, the MAPK targets of Ste7, are required for mating(7,8), but their role in invasive growth has been unclear.

引用

页码：85 / 88

页数：4

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