Development of liver dysfunction after delivery is possibly due to postpartum autoimmune hepatitis. A report of three cases

被引：21

作者：

Izumi, Y

Kaneko, A

Oku, K

Kimura, M

Tanaka, S

Tada, H

Tatsumi, K

Takano, T

Hidaka, Y

Amino, N

机构：

[1] Osaka Univ, Grad Sch Med, Dept Lab Med, Suita, Osaka, Japan

[2] Osaka Natl Hosp, Dept Gastroenterol, Osaka, Japan

[3] Takanohara Cent Hosp, Nara, Japan

来源：

JOURNAL OF INTERNAL MEDICINE | 2002年 / 252卷 / 04期

关键词：

anti-CYP2D6; antibodies; liver dysfunction; postpartum autoimmune hepatitis; pregnancy;

D O I：

10.1046/j.1365-2796.2002.01047.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune diseases, especially autoimmune thyroid disease, frequently develop after delivery due to the immune rebound mechanism. Most cases involve transient dysfunction of affected organs. We examined three patients who developed liver dysfunction after delivery. They were all diagnosed with definite or probable autoimmune hepatitis using the scoring system of the International Autoimmune Hepatitis Group. Moreover, all of them had anti-CYP2D6 antibodies detected by a sensitive radioligand assay. Our findings strongly suggest that liver dysfunction is induced by postpartum autoimmune hepatitis, and clinicians should be aware of this disease.

引用

页码：361 / 367

页数：7

共 16 条

[1] International Autoimmune Hepatitis Group Report:: review of criteria for diagnosis of autoimmune hepatitis [J].

Alvarez, E ;

Berg, PA ;

Bianchi, FB ;

Bianchi, L ;

Burroughs, AK ;

Cancado, EL ;

Chapman, RW ;

Cooksley, WGE ;

Czaja, AJ ;

Desmet, VJ ;

Donaldson, RT ;

Eddleston, ALWF ;

Fainboim, L ;

Heathcote, J ;

Homberg, JC ;

Hoofnagle, JH ;

Kakumu, S ;

Krawitt, EL ;

Mackay, IR ;

MacSween, RNM ;

Maddrey, WC ;

Manns, MP ;

McFarlane, IG ;

zum Büschenfelde, KHM ;

Mieli-Vergani, G ;

Nakanuma, Y ;

Nishioka, M ;

Penner, E ;

Porta, G ;

Portmann, BC ;

Reed, WD ;

Rodes, J ;

Schalm, SW ;

Scheuer, PJ ;

Schrumpf, E ;

Seki, T ;

Toda, G ;

Tsuji, T ;

Tygstrup, N ;

Vergani, D ;

Zeniya, M .

JOURNAL OF HEPATOLOGY, 1999, 31 (05) :929-938

[2] Postpartum autoimmune thyroid syndrome: A model of aggravation of autoimmune disease [J].

Amino, N ;

Tada, H ;

Hidaka, Y .

THYROID, 1999, 9 (07) :705-713

[3] HIGH PREVALENCE OF TRANSIENT POSTPARTUM THYROTOXICOSIS AND HYPOTHYROIDISM [J].

AMINO, N ;

MORI, H ;

IWATANI, Y ;

TANIZAWA, O ;

KAWASHIMA, M ;

TSUGE, I ;

IBARAGI, K ;

KUMAHARA, Y ;

MIYAI, K .

NEW ENGLAND JOURNAL OF MEDICINE, 1982, 306 (14) :849-852

[4] Postpartum autoimmune thyroid syndrome [J].

Amino, N ;

Tada, H ;

Hidaka, Y ;

Izumi, Y .

ENDOCRINE JOURNAL, 2000, 47 (06) :645-655

[5] Remission of autoimmune hepatitis during pregnancy: a report of two cases [J].

Colle, I ;

Hautekeete, M .

LIVER, 1999, 19 (01) :55-57

[6] Management and outcome of pregnancy in autoimmune hepatitis [J].

Heneghan, MA ;

Norris, SM ;

O'Grady, JG ;

Harrison, PM ;

McFarlane, IG .

GUT, 2001, 48 (01) :97-102

[7] Prediction of postpartum onset of rheumatoid arthritis [J].

Iijima, T ;

Tada, H ;

Hidaka, Y ;

Yagoro, A ;

Mitsuda, N ;

Kanzaki, T ;

Murata, Y ;

Amino, N .

ANNALS OF THE RHEUMATIC DISEASES, 1998, 57 (08) :460-463

[8] MEETING REPORT - INTERNATIONAL-AUTOIMMUNE-HEPATITIS-GROUP [J].

JOHNSON, PJ ;

MCFARLANE, IG ;

ALVAREZ, F ;

BIANCHI, FB ;

BIANCHI, L ;

BURROUGHS, A ;

CHAPMAN, RW ;

CZAJA, AJ ;

DESMET, V ;

EDDLESTON, ALWF ;

GERBER, MA ;

HOFFNAGLE, JH ;

KAKUMU, S ;

MACSWEEN, RNM ;

MADDREY, WC ;

MANNS, MP ;

ZUMBUSCHENFELDE, KHM ;

MIELIVERGANI, G ;

PORTMANN, BC ;

REED, WD ;

SCHALM, SW ;

SCHEUER, PJ ;

TODA, G ;

TSUJI, T ;

TYGSTRUP, N ;

VERGANI, D ;

ZENIYA, M .

HEPATOLOGY, 1993, 18 (04) :998-1005

[9] Anti-CYP2D6 antibodies detected by quantitative radioligand assay and relation to antibodies to liver-specific arginase in patients with autoimmune hepatitis [J].

Kimura, M ;

Tatsumi, K ;

Tada, H ;

Izumi, Y ;

Kaneko, A ;

Kato, M ;

Masuzawa, M ;

Ikemoto, M ;

Yabusaki, Y ;

Hidaka, Y ;

Amino, N .

CLINICA CHIMICA ACTA, 2002, 316 (1-2) :155-164

[10] Immunosuppressive effect of pregnancy on autoimmune hepatitis: a case report and review of literature [J].

Malhotra, B ;

Malhotra, N ;

Deka, D ;

Takkar, D .

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2002, 101 (01) :91-92

← 1 2 →