Copper-Catalyzed Decarboxylative C-P Cross-Coupling of Alkynyl Acids with H-Phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides

被引：97
作者：
Hu, Gaobo
Gao, Yuxing [1 ]
Zhao, Yufen
机构：
[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 17期
关键词：
TERMINAL ALKYNES; DIPHENYLPHOSPHINE OXIDE; VINYLPHOSPHINE OXIDES; INTERMOLECULAR HYDROPHOSPHINATION; STEREOSELECTIVE ADDITION; STEREOSPECIFIC CLEAVAGE; TRANSFER HYDROGENATION; CONJUGATE ADDITION; ARYLBORONIC ACIDS; RADICAL-ADDITION;
D O I：
10.1021/ol502009b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and the stereoselectivity for E-isomers.
引用
收藏
页码：4464 / 4467
页数：4
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