oqxAB Encoding a Multidrug Efflux Pump in Human Clinical Isolates of Enterobacteriaceae

被引：217
作者：
Kim, Hong Bin [1 ,2 ,3 ]
Wang, Minghua [1 ,4 ]
Park, Chi Hye [1 ]
Kim, Eui-Chong [5 ]
Jacoby, George A. [6 ]
Hooper, David C. [1 ]
机构：
[1] Massachusetts Gen Hosp, Div Infect Dis, 55 Fruit St, Boston, MA 02114 USA
[2] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea
[4] Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai 200433, Peoples R China
[5] Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
[6] Lahey Clin Fdn, Burlington, MA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 08期
关键词：
ESCHERICHIA-COLI; PLASMID; RESISTANCE; OLAQUINDOX;
D O I：
10.1128/AAC.01574-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The genes for multidrug efflux pump OqxAB, which is active on fluoroquinolones, were found in human clinical isolates on a plasmid in Escherichia coli and on the chromosome of Klebsiella pneumoniae. IS26-like sequences flanked the plasmid-mediated oqxAB genes, suggesting that they had been mobilized as part of a composite transposon.
引用
收藏
页码：3582 / 3584
页数：3
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