Tlr4: central component of the sole mammalian LPS sensor

被引：637

作者：

Beutler, B ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Howard Hughes Med Inst, Dallas, TX 75235 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)00046-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

引用

页码：20 / 26

页数：7

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