Tlr4: central component of the sole mammalian LPS sensor

被引：637

作者：

Beutler, B ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Howard Hughes Med Inst, Dallas, TX 75235 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)00046-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

引用

页码：20 / 26

页数：7

共 50 条

[1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].

Adachi, O ;

Kawai, T ;

Takeda, K ;

Matsumoto, M ;

Tsutsui, H ;

Sakagami, M ;

Nakanishi, K ;

Akira, S .

IMMUNITY, 1998, 9 (01) :143-150

[2] Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [J].

Aliprantis, AO ;

Yang, RB ;

Mark, MR ;

Suggett, S ;

Devaux, B ;

Radolf, JD ;

Klimpel, GR ;

Godowski, P ;

Zychlinsky, A .

SCIENCE, 1999, 285 (5428) :736-739

[3] ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - GENETIC-STUDIES ON THE ROLE OF THE TOLL GENE-PRODUCT [J].

ANDERSON, KV ;

JURGENS, G ;

NUSSLEINVOLHARD, C .

CELL, 1985, 42 (03) :779-789

[4] A conserved signaling pathway: The Drosophila Toll-Dorsal pathway [J].

Belvin, MP ;

Anderson, KV .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :393-416

[5] COMPARATIVE STUDIES ON TOXICITY OF ESCHERICHIA COLI LIPOPOLYSACCHARIDE ENDOTOXIN IN VARIOUS ANIMAL SPECIES [J].

BERCZI, I ;

BERTOK, L ;

BEREZNAI, T .

CANADIAN JOURNAL OF MICROBIOLOGY, 1966, 12 (05) :1070-+

[6] EFFECT OF GAMMA-INTERFERON ON CACHECTIN EXPRESSION BY MONONUCLEAR PHAGOCYTES - REVERSAL OF THE LPSD (ENDOTOXIN RESISTANCE) PHENOTYPE [J].

BEUTLER, B ;

TKACENKO, V ;

MILSARK, I ;

KROCHIN, N ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (05) :1791-1796

[7] CONTROL OF CACHECTIN (TUMOR-NECROSIS-FACTOR) SYNTHESIS - MECHANISMS OF ENDOTOXIN RESISTANCE [J].

BEUTLER, B ;

KROCHIN, N ;

MILSARK, IW ;

LUEDKE, C ;

CERAMI, A .

SCIENCE, 1986, 232 (4753) :977-980

[8] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[9] GENETIC BASIS FOR UNRESPONSIVENESS TO LIPOPOLYSACCHARIDE IN C57BL-10CR MICE [J].

COUTINHO, A ;

MEO, T .

IMMUNOGENETICS, 1978, 7 (01) :17-24

[10] Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor [J].

Du, X ;

Poltorak, A ;

Silva, M ;

Beutler, B .

BLOOD CELLS MOLECULES AND DISEASES, 1999, 25 (21) :328-338

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