Mesenchymal Stem Cells Regulate Cytoskeletal Dynamics and Promote Cancer Cell Invasion Through Low Dose Nitric Oxide

被引：0
作者：
Zhang, L. [1 ,2 ,3 ]
Sun, J. [4 ]
Liu, Z. [3 ]
Dai, Y. [4 ]
Luo, Z. [4 ]
Jiang, X. [6 ]
Li, Z. [4 ]
Li, Y. [7 ]
Cao, P. [4 ]
Zhou, Y. [1 ,2 ,4 ]
Zeng, Z. [1 ,2 ,4 ]
Tang, A. [5 ]
Li, X. [1 ,2 ,5 ]
Li, X. [1 ,2 ,5 ]
Xiang, J. [1 ,2 ,4 ,5 ]
Li, G. [1 ,2 ,4 ,5 ]
机构：
[1] Cent S Univ, Hunan Prov Tumor Hosp, Changsha, Hunan, Peoples R China
[2] Cent S Univ, Affiliated Tumor Hosp, Xiangya Med Sch, Changsha, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
[4] Cent S Univ, Minist Hlth, Canc Res Inst,Key Lab Carcinogenesis, Key Lab Carcinogenesis & Canc Invas,Minist Educ, Changsha 410078, Hunan, Peoples R China
[5] Hunan Key Lab Nonresolving Inflammat & Canc, Changsha 410013, Hunan, Peoples R China
[6] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
[7] Cent S Univ, Xiangya Hosp, Dept Bone Surg, Changsha 410008, Hunan, Peoples R China
来源：
CURRENT MOLECULAR MEDICINE | 2014年 / 14卷 / 06期
关键词：
Bone marrow-derived mesenchymal stem cells; invadopodia; matrix degradation; metastasis; nasopharyngeal carcinoma; nitric oxide; MATRIX DEGRADATION; EXPRESSION; MIGRATION; INVADOPODIA; CALDESMON; DIFFERENTIATION; METASTASIS; PODOSOMES;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of macrophages. Nitric oxide produced by BMSCs in tumor environment could translocate caldesmon to podosome in Ca2+/calmodulin manner and promoted metastatic ability of NPC cells through invadopodia formation, with which the NPC cells degrade the extracellular matrix. Thus, we concluded that the BMSCs promoted cell migration and invasion through nitric oxide-induced paracrine signals.
引用
收藏
页码：749 / 761
页数：13
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