Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

被引：67

作者：

Teixeira de Sousa, Maria da Gloria ^{[1
,2
]}

Belda, Walter, Jr. ^{[3
]}

Spina, Ricardo ^{[3
]}

Lota, Priscila Ramos ^{[3
]}

Valente, Neusa Sakai ^{[3
]}

Brown, Gordon D. ^{[4
]}

Criado, Paulo Ricardo ^{[3
]}

Benard, Gil ^{[1
,2
]}

机构：

[1] Univ Sao Paulo, Sch Med, Clin Hosp, Lab Med Invest,Unit 53,Div Clin Dermatol, BR-05508 Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Med, Clin Hosp, Lab Med Mycol,Trop Med Inst, BR-05508 Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Med, Clin Hosp, Div Clin Dermatol, BR-05508 Sao Paulo, Brazil

[4] Univ Aberdeen, Inst Med Sci, Aberdeen Fungal Grp, Aberdeen AB9 1FX, Scotland

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 12期

基金：

英国惠康基金;

关键词：

Imiquimod; chromoblastomycosis; Fonsecaea pedrosoi; innate immunity; antifungal treatment; CUTANEOUS LEISHMANIASIS; MEGLUMINE ANTIMONIATE; CYTOKINES; INFECTION; 5-PERCENT; TRIAL; FORMS; SKIN;

D O I：

10.1093/cid/ciu168

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.

引用

页码：1734 / 1737

页数：4

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