Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

被引：24

作者：

Feng, Xuepeng ^{[1
]}

Wang, Guirong ^{[1
]}

Neumann, Kevin ^{[2
]}

Yao, Wei ^{[1
]}

Ding, Lin ^{[1
]}

Li, Songyan ^{[1
]}

Sheng, Yang ^{[1
]}

Jiang, Yan ^{[1
]}

Bradley, Mark ^{[2
]}

Zhang, Rong ^{[1
]}

机构：

[1] Changzhou Univ, Sch Mat Sci & Engn, Changzhou 213164, Peoples R China

[2] Univ Edinburgh, Sch Chem, EaStCHEM, Joseph Black Bldg, Edinburgh EH9 3FJ, Midlothian, Scotland

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 74卷

基金：

中国国家自然科学基金;

关键词：

Poly(ether-ester); Polyurethane acrylates; Biodegradable; Controlled drug release; Tetracycline; EFFICIENT INTRACELLULAR RELEASE; AMPHIPHILIC BLOCK-COPOLYMERS; POLY(CARBONATE URETHANE); BIOMEDICAL APPLICATIONS; SUSTAINED-RELEASE; ANTICANCER DRUGS; IN-VIVO; POLYURETHANE; DELIVERY; MICELLES;

D O I：

10.1016/j.msec.2016.12.009

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Three polyether-ester triblock diols, with various molecular weights, were synthesized from epsilon-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200 h, suggesting that the polymers could be used as an implant coating for controlled drug release.(C) 2016 Elsevier B.V. All rights reserved.

引用

页码：270 / 278

页数：9

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