Patient factors associated with lung transplant referral and waitlist for patients with cystic fibrosis and pulmonary fibrosis

被引:11
作者
Liu, Yuan [1 ]
Vela, Monica [1 ,2 ]
Rudakevych, Tanya [3 ,4 ]
Wigfield, Christopher [5 ]
Garrity, Edward [5 ]
Saunders, Milda R. [4 ]
机构
[1] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Med, Gen Internal Med Sect, Chicago, IL 60637 USA
[3] Univ Chicago, Dept Stat, Chicago, IL 60637 USA
[4] Univ Chicago, Dept Med, Sect Hosp Med, Chicago, IL 60637 USA
[5] Univ Chicago, Lung Transplant Program, Chicago, IL 60637 USA
关键词
cystic fibrosis; lung transplarit; pulmonary fibrosis; waitlist; access to healthcare; socioeconomic factors; SYSTEMIC-LUPUS-ERYTHEMATOSUS; UNITED-STATES; INTERNATIONAL-SOCIETY; SELECTION; CANDIDATES; OBESITY; ACCESS; HEART; DISPARITIES; OUTCOMES;
D O I
10.1016/j.healun.2016.08.016
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: Since 2005, the Lung Allocation Score (LAS) has prioritized patient benefit and post transplant survival, reducing waitlist to transplant time to <200 days and decreasing mortality on the waitlist. A current challenge is the wait for the waitlist the time between the patient's transplant eligible diagnosis and waitlist registration. METHODS: We investigated whether sociodemographic (age, sex, race, insurance, marital status, median household income) and clinical (forced expiratory volume in 1 second [FEV1] percent of predicted, body mass index, depression/anxiety, alcohol/substance misuse, absolute/relative contraindications) factors influenced referral and waitlist registration. We conducted a retrospective cohort study through chart review of hospitalized patients on the University of Chicago general medicine service from 2006 to 2014 who met transplant-eligible criteria and ICD-9 billing codes for cystic fibrosis (CF) and pulmonary fibrosis (PF). We analyzed the times from transplant eligibility to referral, work-up and waitlisting using Kaplan-Meier curves and log-rank tests. RESULTS: Overall, the referral rate for transplant-eligible patients was 64%. Of those referred, approximately 36% reach the lung transplant waitlist. Referred CF patients were significantly more likely to reach the transplant waitlist than PF patients (CF 60% vs PF 22%, p < 0.05). In addition, CF patients had a shorter wait from transplant eligibility to waitlist than PF patients (329 vs 2,369 days, respectively [25th percentile], p < 0.05). Patients with PF and CF both faced delays from eligibility to referral and waitlist. CONCLUSIONS: Quality improvement efforts are needed to better identify and refer appropriate patients for lung transplant evaluation. Targeted interventions may facilitate more efficient evaluation completion and waitlist appearance. (C) 2017 International Society for Heart and Lung Transplantation. All rights reserved.
引用
收藏
页码:264 / 271
页数:8
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