Studies on Hypoxic Pulmonary Vasoconstriction Detect a Novel Role for the Mitochondrial Complex I Subunit Ndufs2 in Controlling Peroxide Generation for Oxygen-Sensing

被引：6
|
作者：
Wolin, Michael S. [1 ]
Alruwaili, Norah [1 ]
Kandhi, Sharath [1 ]
机构：
[1] New York Med Coll, Dept Physiol, Basic Sci Bldg,Room 604, Valhalla, NY 10595 USA
来源：
CIRCULATION RESEARCH | 2019年 / 124卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Editorial; hydrogen peroxide; hypoxia; mitochondria; nitroblue tetrazolium; vasoconstriction; SUPEROXIDE; SITES;
D O I：
10.1161/CIRCRESAHA.119.315137
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The molecular mechanisms for the oxygen sensor that appears to be present in pulmonary arterial smooth muscle cells (PASMC) mediating hypoxic pulmonary vasoconstriction (HPV) have been the focus of extensive research and remain controversial.1,2 In this issue of Circulation Research, Dunham-Snary et al3 describe a novel involvement of the mitochondrial electron transport chain (ETC) rotenone binding site complex I subunit, Ndufs2 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 2), in controlling an oxygendependent vasodilator source of peroxide generation that appears to contribute to acute HPV. © 2019 American Heart Association, Inc.
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收藏
页码：1683 / 1685
页数：3
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