Directed cell growth in multi-zonal scaffolds for cartilage tissue engineering

被引：113

作者：

Camarero-Espinosa, Sandra ^{[1
]}

Rothen-Rutishauser, Barbara ^{[1
]}

Weder, Christoph ^{[1
]}

Foster, E. Johan ^{[1
,2
]}

机构：

[1] Univ Fribourg, Adolphe Merkle Inst, CH-1700 Fribourg, Switzerland

[2] Virginia Tech, Macromol & Interfaces Inst, Dept Mat Sci & Engn, Ctr Sustainable Nanotechnol, Blacksburg, VA 24061 USA

来源：

BIOMATERIALS | 2016年 / 74卷

基金：

瑞士国家科学基金会;

关键词：

Cartilage; Scaffold; Tissue-engineering; Multi-layer; Nanocomposite; ARTICULAR-CARTILAGE; MECHANICAL-PROPERTIES; CONFINED COMPRESSION; CELLULOSE; MORPHOLOGY; BONE; COMPOSITES; DESIGN; REPAIR;

D O I：

10.1016/j.biomaterials.2015.09.033

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Articular cartilage serves as a low-friction cushion in synovial joints and is vital for mammalian skeletal movements. Due to its avascular nature and the low cell density, the tissue has a limited ability to regenerate, and damage due to injury, wear and tear, or disease usually requires surgical intervention. While articular cartilage had been predicted to be one of the first tissues to be successfully engineered, it proved to be challenging to reproduce the complex architecture and biomechanical properties of the native tissue. Here we report the fabrication of multi-layer polymer nanocomposite scaffolds that mimic the structural design, chemical cues, and mechanical characteristics of mature articular cartilage. These scaffolds guide the morphology, orientation, and phenotypic state of cultured chondrocytes in a spatially controlled manner, support the growth of tissue with features that are reminiscent of the natural analogue, and promote localized hydroxyapatite formation to permit integration with the subchondral bone. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：42 / 52

页数：11

共 54 条

[1] CARTILAGE SELF-HEATING CONTRIBUTES TO CHONDROGENIC EXPRESSION [J].

Abdel-Sayed, Philippe ;

Vogel, Arne ;

Moghadam, Mohamadreza Nassajian ;

Pioletti, Dominique P. .

EUROPEAN CELLS & MATERIALS, 2013, 26 :171-178

[2] Flow properties of microcrystalline cellulose suspension prepared by acid treatment of native cellulose [J].

Araki, J ;

Wada, M ;

Kuga, S ;

Okano, T .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 1998, 142 (01) :75-82

[3]

Athanasiou K.A., 2009, Synthesis Lectures on Tissue Engineering, V1, P1, DOI [DOI 10.2200/S00212ED1V01Y200910TIS003, 10.2200/S00212ED1V01Y200910TIS003]

[4] INTERSPECIES COMPARISONS OF INSITU INTRINSIC MECHANICAL-PROPERTIES OF DISTAL FEMORAL CARTILAGE [J].