Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Ivacaftor Therapy in the Context of CFTR Genotype

被引：44

作者：

Clancy, J. P. ^{[1
,2
]}

Johnson, S. G. ^{[3
,4
]}

Yee, S. W. ^{[5
]}

McDonagh, E. M. ^{[6
]}

Caudle, K. E. ^{[7
]}

Klein, T. E. ^{[6
]}

Cannavo, M. ^{[7
]}

Giacomini, K. M. ^{[5
]}

机构：

[1] Cincinnati Childrens Hosp, Med Ctr, Div Pulm Med, Cincinnati, OH USA

[2] Univ Cincinnati, Dept Pediat, Cincinnati, OH 45221 USA

[3] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, Denver, CO 80202 USA

[4] Kaiser Permanente Colorado, Clin Pharm Serv, Denver, CO USA

[5] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

[6] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA

[7] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2014年 / 95卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TRANSMEMBRANE CONDUCTANCE REGULATOR; CYSTIC-FIBROSIS GENE; PERICILIARY LIQUID; IN-VITRO; MUTATION; IDENTIFICATION; PATHOGENESIS; INFLAMMATION; POTENTIATOR; CHANNEL;

D O I：

10.1038/clpt.2014.54

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cystic fibrosis (CF) is a life-shortening disease arising as a consequence of mutations within the CFTR gene. Novel therapeutics for CF are emerging that target CF transmembrane conductance regulator protein (CFTR) defects resulting from specific CFTR variants. Ivacaftor is a drug that potentiates CFTR gating function and is specifically indicated for CF patients with a particular CFTR variant, G551D-CFTR (rs75527207). Here, we provide therapeutic recommendations for ivacaftor based on preemptive CFTR genotype results.

引用

页码：592 / 597

页数：6

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