Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties

被引：22

作者：

De Marino, Simona ^{[1
]}

Festa, Carmen ^{[1
]}

D'Auria, Maria Valeria ^{[1
]}

Bourguet-Kondracki, Marie-Lise ^{[2
]}

Petek, Sylvain ^{[3
]}

Debitus, Cecile ^{[4
]}

Maria Andres, Rosa ^{[5
]}

Carmen Terencio, Maria ^{[5
]}

Paya, Miguel ^{[5
]}

Zampella, Angela ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, Via D Montesano 49, I-80131 Naples, Italy

[2] MNHN, Lab Chim & Biochim Substances Nat, F-75005 Paris, France

[3] IRD, UMR152, Noumea, New Caledonia

[4] IRD, UMR152, Papeete, Tahiti, France

[5] Univ Valencia, Fac Farm, Dept Farmacol, E-46100 Valencia, Spain

来源：

TETRAHEDRON | 2009年 / 65卷 / 15期

关键词：

CONTAINING CLERODANE DITERPENOIDS; INHIBITORS; ECHINOPHYLLINS; SUVANINE; POTENT; ASSAY;

D O I：

10.1016/j.tet.2009.02.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Investigation of the marine sponge Coscinoderma mathewsi led to the isolation of two novel nitrogen-containing cheilanthane sesterterpenoids, coscinolactams A and B, together with known suvanine. The structures were elucidated by extensive spectroscopic measurements including NOE experiments to deduce the stereochemistry. The natural compounds, as well as a semisynthetic derivative, showed moderate anti-inflammatory activity measured as their capability to inhibit PGE(2) and NO production. The suvanine aldehyde derivative 4 inhibited inducible nitric oxide protein expression with an IC50 value of 7.3 mu M. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2905 / 2909

页数：5

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