Treatment of hepatitis B virus (HBV) in the setting of HIV-HBV co-infection

被引：0
作者：
Iser, David M. [1 ,2 ]
Lewin, Sharon R. [1 ,3 ]
机构：
[1] Univ Melbourne, St Vincents Hosp, Dept Med, Fitzroy, Vic 3065, Australia
[2] Alfred Hosp, Infect Dis Unit, Melbourne, Vic 3004, Australia
[3] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia
来源：
ASIAN BIOMEDICINE | 2009年 / 3卷 / 01期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
Hepatitis; HIV-HBV co-infection; liver fibrosis; HUMAN-IMMUNODEFICIENCY-VIRUS; TENOFOVIR DISOPROXIL FUMARATE; ACTIVE ANTIRETROVIRAL THERAPY; T-CELL RESPONSES; ADEFOVIR DIPIVOXIL; E-ANTIGEN; PEGINTERFERON ALPHA-2A; INFECTED PATIENTS; NATURAL-HISTORY; C VIRUS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Liver disease in individuals with HIV-HBV co-infection is now a major cause of mortality worldwide, including Asia. The pathogenesis of liver disease in this setting is multifactorial, but includes drug toxicity and immunological factors, such as immune restoration disease. Staging of chronic hepatitis B is important prior to commencement of anti-retroviral therapy and should include quantification of HBV DNA, and, where possible, an assessment of liver fibrosis, either by liver biopsy or non-invasive measurement. Earlier treatment of both HIV and HBV is now generally advocated, and treatment is usually life-long.
引用
收藏
页码：15 / 27
页数：13
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