At-Home IVF Kit: application during the COVID-19 pandemic

被引:3
作者
Merhi, Z. [1 ,2 ,3 ]
Zhang, J. [1 ,2 ]
机构
[1] SUNY Downstate Hlth Sci Univ, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, New York, NY 10019 USA
[2] New Hope Fertil Ctr, 4 Columbus Circle,4th Floor, New York, NY 10019 USA
[3] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10463 USA
关键词
IVF; Home; Coronavirus; COVID-19; Oocyte freezing; Pandemic; MEDROXYPROGESTERONE ACETATE; STIMULATION; ELAGOLIX; WOMEN;
D O I
10.31083/j.ceog.2020.05.2157
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The guidelines, at the time of writing this manuscript, recommend withholding fertility treatments due to fear of the COVID-19. However, many fertility doctors and many patients, especially those with diminished ovarian reserve (DOR), strongly suggest that their fertility treatment including oocyte and/or embryo freezing is a time-sensitive matter due to fear of losing all their ovarian reserve. This report presents a novel approach for ovarian stimulation at home in women with DOR for oocyte/embryo cryopreservation using At-HOME IVF kit mailed to the patients' home, and without the need for blood hormones and transvaginal ultrasounds monitoring. In this study, women (n = 22) diagnosed with DOR who underwent either oocyte (n = 6) or embryo freezing (n = 16) were included. Each patient took the medications included in the kit without the frequent visits to the office for monitoring and presented only once to the fertility clinic on the day of the oocyte retrieval. Upon presentation on the day of oocyte retrieval, none of the patients had ovulated. All patients underwent oocyte retrieval with 21 out of 22 patients having had at least one or more oocytes collected, with the number of mature oocytes retrieved ranging from 1 to 7. Eight out of 16 patients (50%) who underwent IVF, had embryos cryopreserved at either the cleavage-stage or blastocyst stage. This report suggests that, during the COVID-19 pandemic, At-HOME IVF kit presents a novel solution for women with DOR, or in situations where time is of essence, limiting office visits and thus minimizing the risk of coronavirus infection.
引用
收藏
页码:653 / 659
页数:7
相关论文
共 15 条
[1]  
Archer DF, 2020, J Clin Endocrinol Metab, V105
[2]   Medroxyprogesterone acetate versus ganirelix in oocyte donation: a randomized controlled trial [J].
Begueria, R. ;
Garcia, D. ;
Vassena, R. ;
Rodriguez, A. .
HUMAN REPRODUCTION, 2019, 34 (05) :872-880
[3]   The pregnancy outcome of progestin-primed ovarian stimulation using 4 versus 10 mg of medroxyprogesterone acetate per day in infertile women undergoing in vitro fertilisation: a randomised controlled trial [J].
Dong, J. ;
Wang, Y. ;
Chai, W. R. ;
Hong, Q. Q. ;
Wang, N. L. ;
Sun, L. H. ;
Long, H. ;
Wang, L. ;
Tian, H. ;
Lyu, Q. F. ;
Lu, X. F. ;
Chen, Q. J. ;
Kuang, Y. P. .
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2017, 124 (07) :1048-1055
[4]   Clinical evaluation of three different gonadotrophin-releasing hormone analogues in an IVF programme: a prospective study [J].
El-Nemr, A ;
Bhide, M ;
Khalifa, Y ;
Al-Mizyen, E ;
Gillott, C ;
Lower, AM ;
Al-Shawaf, T ;
Grudzinskas, JG .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2002, 103 (02) :140-145
[5]   Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [J].
Hajishafiha, Masomeh ;
Dehghan, Meisam ;
Kiarang, Nazila ;
Sadegh-Asadi, Nahideh ;
Shayegh, Seyed Navid ;
Ghasemi-Rad, Mohammad .
DRUG DESIGN DEVELOPMENT AND THERAPY, 2013, 7 :1427-1431
[6]   Impact of telemedicine on assisted reproduction treatment in the public health system [J].
Hernandez, C. ;
Valdera, C. J. ;
Cordero, J. ;
Lopez, E. ;
Plaza, J. ;
Albi, M. .
JOURNAL OF HEALTHCARE QUALITY RESEARCH, 2020, 35 (01) :27-34
[7]   Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization [J].
Kuang, Yanping ;
Chen, Qiuju ;
Fu, Yonglun ;
Wang, Yun ;
Hong, Qingqing ;
Lyu, Qifeng ;
Ai, Ai ;
Shoham, Zeev .
FERTILITY AND STERILITY, 2015, 104 (01) :62-+
[8]   COVID-19: lessons from the Italian reproductive medical experience [J].
La Marca, Antonio ;
Niederberger, Craig ;
Pellicer, Antonio ;
Nelson, Scott M. .
FERTILITY AND STERILITY, 2020, 113 (05) :920-922
[9]   A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome [J].
Mejia, Rachel B. ;
Summers, Karen M. ;
Kresowik, Jessica D. ;
Van Voorhis, Bradley J. .
FERTILITY AND STERILITY, 2019, 111 (03) :571-+
[10]   Mild stimulation for in vitro fertilization [J].
Nargund, Geeta ;
Datta, Adrija Kumar ;
Fauser, Bart C. J. M. .
FERTILITY AND STERILITY, 2017, 108 (04) :558-567