Versatile "on-off" biosensing of thrombin and miRNA based on Ag(i) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

被引：45

作者：

Ge, Junjun ^{[1
]}

Li, Chunli ^{[1
]}

Zhao, Yu ^{[1
]}

Yu, Xijuan ^{[1
]}

Jie, Guifen ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Key Lab Opt Elect Sensing & Analyt Chem Life Sci, Key Lab Analyt Chem Life Sci Univ Shandong, Shandong Key Lab Biochem Anal,Coll Chem & Mol Eng, Qingdao 266042, Shandong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 51期

基金：

中国国家自然科学基金;

关键词：

MESOPOROUS SILICA NANOPARTICLES; DNA WALKING; NITROGEN; RELEASE; SULFUR;

D O I：

10.1039/c9cc03235e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel biosensing platform based on the Ag(i) ion-enhanced or Ag nanocluster (NC)-quenched electrochemiluminescence (ECL) of CdSe quantum dots (QDs) was designed for versatile "on-off" assays of thrombin (TB) and miRNA, in which bipedal molecular machine (BMM)-triggered surface programmatic chain reaction (SPCR) coupled with mesoporous silica nanoparticle (MSN) multiple amplification is used to introduce plentiful QDs and Ag+ ions to significantly improve the ECL signal.

引用

页码：7350 / 7353

页数：4

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