Development of Nano-hydroxyapatite/Polycarbonate Composite for Bone Repair

被引：14
|
作者：
Liao Jianguo [3 ]
Zhang Li [1 ,2 ]
Zuo Yi [1 ,2 ]
Wang Huanan [1 ,2 ]
Li Jidong [1 ,2 ]
Zou Qin [1 ,2 ]
Li Yubao [1 ,2 ]
机构：
[1] Sichuan Univ, Res Ctr Nanobiomat, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Peoples R China
[3] Henan Polytechn Univ, Sch Mat Sci & Engn, Jiaozuo 454000, Peoples R China
来源：
JOURNAL OF BIOMATERIALS APPLICATIONS | 2009年 / 24卷 / 01期
关键词：
nano-hydroxyapatite; polycarbonate; bone substitute; biocompatibility; composite; SURFACE MODIFICATION; APATITE; GROWTH;
D O I：
10.1177/0885328209102756
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this study, nano-hydroxyapatite (n-HA) combined polycarbonate was synthesized by a novel method. The physical and chemical property of the composite was tested. The results indicated the n-HA a crystal has the similar grain size, phase composition and crystal structure as. TEM photos results show the n-HA crystals were uniformly distributed in the polymer matrix. Then, the chemical bond between inorganic n-HA and polycarbonate was investigated and discussed. Proliferation of MSCs/composite cultured for up to 11 days the adhesion were tested by MTT and SEM. The in vitro test confirmed that the n-HA/PC composite was biocompatible and no negative effect on MSCs has found. The composite is proved to be osteoconductive, and can stimulate the growth of new bone. These results indicated that the composite meet the basic requirement of bone substitute material, and be potentially applied for clinic.
引用
收藏
页码：31 / 45
页数：15
相关论文
共 50 条
  • [41] Effect of nano-hydroxyapatite on protein adsorption and cell adhesion of poly(lactic acid)/nano-hydroxyapatite composite microspheres
    Wijerathne, H. M. C. Suboda
    Yan, Dong
    Zeng, Bin
    Xie, Yanping
    Hu, Hongchao
    Wickramaratne, M. Nirmali
    Han, Yingchao
    SN APPLIED SCIENCES, 2020, 2 (04):
  • [42] Preparation and biological properties of collagen/nano-hydroxyapatite composite nanofibers based on ordered nano-hydroxyapatite ceramic fibers
    Bian, Tierong
    Zhang, Heng
    Xing, Hongyun
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2020, 602
  • [43] A sandwich-like structure composite electrospun membrane of polylactic acid/nano-hydroxyapatite and polyvinyl alcohol/sodium alginate/nano-hydroxyapatite for skull defect repair
    Feng, Tianyi
    Liang, Bangbang
    Bi, Hongyan
    Han, Yingchao
    MATERIALS & DESIGN, 2021, 209
  • [44] Development of nano-hydroxyapatite/chitosan composite for cadmium ions removal in wastewater treatment
    Salah, Taher A.
    Mohammad, Ahmad M.
    Hassan, Mohamed A.
    El-Anadouli, Bahgat E.
    JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2014, 45 (04) : 1571 - 1577
  • [45] Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering
    Mo, Xiaojing
    Zhang, Dianjian
    Liu, Keda
    Zhao, Xiaoxi
    Li, Xiaoming
    Wang, Wei
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (02)
  • [46] A nano-hydroxyapatite - Pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering
    Fricain, Jean Christophe
    Schlaubitz, Silke
    Le Visage, Catherine
    Arnault, Isabelle
    Derkaoui, Sidi Mohammed
    Siadous, Robin
    Catros, Sylvain
    Lalande, Charlotte
    Bareille, Reine
    Renard, Martine
    Fabre, Thierry
    Cornet, Sandro
    Durand, Marlene
    Leonard, Alain
    Sahraoui, Nouredine
    Letourneur, Didier
    Amedee, Joelle
    BIOMATERIALS, 2013, 34 (12) : 2947 - 2959
  • [47] Effects of nano-hydroxyapatite content on bone formation in nano-hydroxyapatite-collagen composite membrane with BMP-2 application
    Tenkumo, Taichi
    Sugaya, Tsutomu
    Kawanami, Masamitsu
    Watari, Fumio
    Nano Biomedicine, 2009, 1 (02): : 159 - 166
  • [48] Study on the biomimetic properties of bone substitute material: Nano-hydroxyapatite/polyamide 66 composite
    Wu, Lan
    Li, YuBao
    Zu, Yi
    Zhang, Li
    Yang, Weihu
    Mu, Yuanhua
    ECO-MATERIALS PROCESSING & DESIGN VII, 2006, 510-511 : 938 - 941
  • [49] Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering
    Wang, Huanan
    Li, Yubao
    Zuo, Yi
    Li, Jihua
    Ma, Sansi
    Cheng, Lin
    BIOMATERIALS, 2007, 28 (22) : 3338 - 3348
  • [50] Degradation and biocompatibility of porous nano-hydroxyapatite/polyurethane composite scaffold for bone tissue engineering
    Dong, Zhihong
    Li, Yubao
    Zou, Qin
    APPLIED SURFACE SCIENCE, 2009, 255 (12) : 6087 - 6091
12345