Increments in circulating thromboinodulin levels reflect endothelial cell injury. Thrombomodulin can also be synthesized by several inflammatory cells including monocytes, neutrophils, and thrombomodulin itself can modulate the inflammatory response. In this study, we assessed circulating thrombomodulin concentrations in patients with familial Mediterranean fever (FMF). Twenty-five patients with IMF (F/M: 14/11) (mean age: 31.1 +/- 9.7 years) and 25 healthy controls (F/M: 13/12) (mean age: 34.6 +/- 7.0 years) were involved in the study. Thrombomodulin levels were measured by commercially available enzyme-linked immunosorbant assay (ELISA) (Immunoassay of thrombomodulin Diagnostica Stago, Asnieres-Sur-Seine, France). Twenty of the patients were in attack-free period and the remaining five had been during acute FMF attacks. Thrombomodulin levels were higher in the study group (20.9 +/- 12.1 ng/ml) than healthy controls (14.1 +/- 8.4 ng/ml) (p < 0.05). Circulating thrombomodulin levels were also higher in attack-free FMF patients (22.4 +/- 12.9 ng/ml) than controls. This study disclosed for the first time significantly higher increments in the circulating levels of thrombomodulin in FMF This observation could be a consequence of injured endothelium and/or activated inflammatory cells.
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
ANTON, PA
TARGAN, SR
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UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
TARGAN, SR
VIGNA, SR
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机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
VIGNA, SR
DURHAM, M
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h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
DURHAM, M
SCHWABE, AD
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h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
SCHWABE, AD
SHANAHAN, F
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h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
ANTON, PA
TARGAN, SR
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
TARGAN, SR
VIGNA, SR
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
VIGNA, SR
DURHAM, M
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
DURHAM, M
SCHWABE, AD
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA
SCHWABE, AD
SHANAHAN, F
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, DEPT MED, DIV GASTROENTEROL, CHS 44-138, LOS ANGELES, CA 90024 USA