Circulating thrombomodulin levels in familial Mediterranean fever

被引:0
作者
Ozbalkan, Z.
Ozturk, M. A.
Onat, A. M.
Ureten, K.
Haznedaroglu, I. C.
Kiraz, S.
Ertenli, A. I.
Kirazli, S.
Calguneri, M.
机构
[1] Hacettepe Univ, Sch Med, Dept Internal Med, Rheumatol Sect, Ankara, Turkey
[2] Hacettepe Univ, Sch Med, Dept Internal Med, Sect Hematol, Ankara, Turkey
关键词
thrombomodulin; endothelial cell; familial Mediterranean fever;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Increments in circulating thromboinodulin levels reflect endothelial cell injury. Thrombomodulin can also be synthesized by several inflammatory cells including monocytes, neutrophils, and thrombomodulin itself can modulate the inflammatory response. In this study, we assessed circulating thrombomodulin concentrations in patients with familial Mediterranean fever (FMF). Twenty-five patients with IMF (F/M: 14/11) (mean age: 31.1 +/- 9.7 years) and 25 healthy controls (F/M: 13/12) (mean age: 34.6 +/- 7.0 years) were involved in the study. Thrombomodulin levels were measured by commercially available enzyme-linked immunosorbant assay (ELISA) (Immunoassay of thrombomodulin Diagnostica Stago, Asnieres-Sur-Seine, France). Twenty of the patients were in attack-free period and the remaining five had been during acute FMF attacks. Thrombomodulin levels were higher in the study group (20.9 +/- 12.1 ng/ml) than healthy controls (14.1 +/- 8.4 ng/ml) (p < 0.05). Circulating thrombomodulin levels were also higher in attack-free FMF patients (22.4 +/- 12.9 ng/ml) than controls. This study disclosed for the first time significantly higher increments in the circulating levels of thrombomodulin in FMF This observation could be a consequence of injured endothelium and/or activated inflammatory cells.
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页码:S95 / S98
页数:4
相关论文
共 26 条
  • [1] Endothelium as an organ system
    Aird, WC
    [J]. CRITICAL CARE MEDICINE, 2004, 32 (05) : S271 - S279
  • [2] ENHANCED NEUTROPHIL CHEMI-LUMINESCENCE IN FAMILIAL MEDITERRANEAN FEVER
    ANTON, PA
    TARGAN, SR
    VIGNA, SR
    DURHAM, M
    SCHWABE, AD
    SHANAHAN, F
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 1988, 8 (02) : 148 - 156
  • [3] BASAR O, 2003, IN PRESS JOINT BONE
  • [4] PRESERVATION OF THROMBOMODULIN ANTIGEN ON VASCULAR AND EXTRAVASCULAR SURFACES
    BOFFA, MC
    BURKE, B
    HAUDENSCHILD, CC
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1987, 35 (11) : 1267 - 1276
  • [5] Genetic abnormalities of the endothelium
    Butany, JW
    Verma, S
    Leask, RL
    Mohsen, B
    Asa, SL
    [J]. MICROSCOPY RESEARCH AND TECHNIQUE, 2003, 60 (01) : 30 - 37
  • [6] The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators
    Centola, M
    Wood, G
    Frucht, DM
    Galon, J
    Aringer, M
    Farrell, C
    Kingma, DW
    Horwitz, ME
    Mansfield, E
    Holland, SM
    O'Shea, JJ
    Rosenberg, HF
    Malech, HL
    Kastner, DL
    [J]. BLOOD, 2000, 95 (10) : 3223 - 3231
  • [7] Successful treatment of rheumatoid arthritis is associated with a reduction in serum sE-selectin and thrombomodulin level
    Çobankara, V
    Özath, D
    Kiraz, S
    Öztürk, A
    Ertenli, I
    Türk, T
    Apras, S
    Haznedaroglu, IC
    Çalgüneri, M
    [J]. CLINICAL RHEUMATOLOGY, 2004, 23 (05) : 430 - 434
  • [8] CONWAY EM, 1992, BLOOD, V80, P1254
  • [9] CONWAY EM, 1993, BLOOD, V81, P726
  • [10] Direskeneli H, 1999, J RHEUMATOL, V26, P1983