Regulation of Monoclonal Antibody Immunotherapy by FcγRIIB

被引：11

作者：

Stopforth, Richard J. ^{[1
]}

Cleary, Kirstie L. S. ^{[1
]}

Cragg, Mark S. ^{[1
]}

机构：

[1] Univ Southampton, Antibody & Vaccine Grp, Canc Sci Unit, Southampton Gen Hosp,Fac Med, Southampton SO16 6YD, Hants, England

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2016年 / 36卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Monoclonal antibody; immunotherapy; antigenic modulation; Fc gamma RIIB; CD32B; immunomodulation; B-CELL RECEPTOR; ANTITUMOR-ACTIVITY; ENGAGEMENT DRIVES; IN-VIVO; ACTIVATION; CD32B; IIB; POLYMORPHISM; EXPRESSION; MECHANISM;

D O I：

10.1007/s10875-016-0247-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies (mAb) are revolutionising the treatment of many different diseases. Given their differing mode of action compared to most conventional chemotherapeutics and small molecule inhibitors, they possess the potential to be independent of common modes of treatment resistance and can typically be combined readily with existing treatments without dose-limiting toxicity. However, treatments with mAb rarely result in cure and so a full understanding of how these reagents work and can be optimised is key for their subsequent improvement. Here we review how an understanding of the biology of the inhibitory Fc receptor, Fc gamma RIIB (CD32B), is leading to the development of improved mAb treatments.

引用

页码：S88 / S94

页数：7

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