Mitochondrial control of apoptosis

被引：1386
作者：
Kroemer, G
Zamzami, N
Susin, SA
机构：
[1] CNRS UPR 420, F-94801 Villejuif, 19 rue Guy Moquet
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 01期
关键词：
D O I：
10.1016/S0167-5699(97)80014-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The apoptotic process can be subdivided into three phases: a death-stimulus-dependent, heterogeneous induction phase, a common effector phase during which the 'decision to die' is taken, and a common degradation phase during which cells acquire the biochemical and morphological features of end-stage apoptosis. Here, Guido Kroemer, Naoufal Zamzami and Santos Susin discuss the implication of mitochondrial events in the apoptotic effector phase.
引用
收藏
页码：44 / 51
页数：8
相关论文
共 71 条
[21]   Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [J].
Graeber, TG ;
Osmanian, C ;
Jacks, T ;
Housman, DE ;
Koch, CJ ;
Lowe, SW ;
Giaccia, AJ .
NATURE, 1996, 379 (6560) :88-91
[22]   Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae [J].
Greenhalf, W ;
Stephan, C ;
Chaudhuri, B .
FEBS LETTERS, 1996, 380 (1-2) :169-175
[23]   PROTECTION BY CYCLOSPORINE-A OF ISCHEMIA REPERFUSION-INDUCED DAMAGE IN ISOLATED RAT HEARTS [J].
GRIFFITHS, EJ ;
HALESTRAP, AP .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1993, 25 (12) :1461-1469
[24]   STRUCTURE-FUNCTION ANALYSIS OF BCL-2 PROTEIN IDENTIFICATION OF CONSERVED DOMAINS IMPORTANT FOR HOMODIMERIZATION WITH BCL-2 AND HETERODIMERIZATION WITH BAX [J].
HANADA, M ;
AIMESEMPE, C ;
SATO, T ;
REED, JC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (20) :11962-11969
[25]   C-ELEGANS CELL-SURVIVAL GENE CED-9 ENCODES A FUNCTIONAL HOMOLOG OF THE MAMMALIAN PROTOONCOGENE BCL-2 [J].
HENGARTNER, MO ;
HORVITZ, HR .
CELL, 1994, 76 (04) :665-676
[26]  
HENNET T, 1993, CANCER RES, V53, P1456
[27]  
HICKISH T, 1994, CANCER RES, V54, P2808
[28]   BCL-2 FUNCTIONS IN AN ANTIOXIDANT PATHWAY TO PREVENT APOPTOSIS [J].
HOCKENBERY, DM ;
OLTVAI, ZN ;
YIN, XM ;
MILLIMAN, CL ;
KORSMEYER, SJ .
CELL, 1993, 75 (02) :241-251
[29]  
Hunter JJ, 1996, MOL CELL BIOL, V16, P877
[30]  
IMBERTI R, 1993, J PHARMACOL EXP THER, V265, P392
12345678