Highly increased familial risks for specific lymphoma subtypes

被引：68

作者：

Goldin, Lynn R. ^{[1
]}

Bjorkholm, Magnus ^{[2
,3
]}

Kristinsson, Sigurdur Y. ^{[2
,3
]}

Turesson, Ingemar ^{[4
]}

Landgren, Ola ^{[1
,2
,3
]}

机构：

[1] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[2] Karolinska Univ Hosp Solna, Dept Med, Div Haematol, Stockholm, Sweden

[3] Karolinska Inst, Stockholm, Sweden

[4] Malmo Univ Hosp, Sect Haematol, Dept Med, Malmo, Sweden

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2009年 / 146卷 / 01期

关键词：

non-Hodgkin lymphoma; diffuse large B-cell lymphoma; follicular lymphoma; Hodgkin lymphoma; familial risk; NON-HODGKIN-LYMPHOMA; SUSCEPTIBILITY LOCI; CLASSIFICATION; AGGREGATION; DISORDERS; NEOPLASMS; SCREEN;

D O I：

10.1111/j.1365-2141.2009.07721.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

引用

页码：91 / 94

页数：4

共 15 条

[1] The non-Hodgkin lymphomas: A review of the epidemiologic literature [J].

Alexander, Dominik D. ;

Mink, Pamela J. ;

Adami, Hans-Olov ;

Chang, Ellen T. ;

Cole, Philip ;

Mandel, Jack S. ;

Trichopoulos, Dimitrios .

INTERNATIONAL JOURNAL OF CANCER, 2007, :1-39

[2] Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database [J].

Altieri, A ;

Bermejo, JL ;

Hemminki, K .

BLOOD, 2005, 106 (02) :668-672

[3]

[Anonymous], 2001, Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissues

[4] A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia [J].

Di Bernardo, Maria Chiara ;

Crowther-Swanepoel, Dalemari ;

Broderick, Peter ;

Webb, Emily ;

Sellick, Gabrielle ;

Wild, Ruth ;

Sullivan, Kate ;

Vijayakrishnan, Jayaram ;

Wang, Yufei ;

Pittman, Alan M. ;

Sunter, Nicola J. ;

Hall, Andrew G. ;

Dyer, Martin J. S. ;

Matutes, Estella ;

Dearden, Claire ;

Mainou-Fowler, Tryfonia ;

Jackson, Graham H. ;

Summerfield, Geoffrey ;

Harris, Robert J. ;

Pettitt, Andrew R. ;

Hillmen, Peter ;

Allsup, David J. ;

Bailey, James R. ;

Pratt, Guy ;

Pepper, Chris ;

Fegan, Chris ;

Allan, James M. ;

Catovsky, Daniel ;

Houlston, Richard S. .

NATURE GENETICS, 2008, 40 (10) :1204-1210

[5] Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database [J].

Goldin, LR ;

Pfeiffer, RM ;

Li, XJ ;

Hemminki, K .

BLOOD, 2004, 104 (06) :1850-1854

[6] Familial aggregation and heterogeneity of non-Hodgkin lymphoma in population-based samples [J].

Goldin, LR ;

Landgren, O ;

McMaster, ML ;

Gridley, G ;

Hemminki, K ;

Li, XJ ;

Mellemkjaer, L ;

Olsen, JH ;

Linet, MS .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (10) :2402-2406

[7] A genome screen of families at high risk for Hodgkin lymphoma: evidence for a susceptibility gene on chromosome 4 [J].

Goldin, LR ;

McMaster, ML ;

Ter-Minassian, M ;

Saddlemire, S ;

Harmsen, B ;

Lalonde, G ;

Tucker, MA .

JOURNAL OF MEDICAL GENETICS, 2005, 42 (07) :595-601

[8] Familial aggregation of Hodgkin lymphoma and related tumors [J].

Goldin, LR ;

Pfeiffer, RM ;

Gridley, G ;

Gail, MH ;

Li, XJ ;

Mellemkjaer, L ;

Olsen, JH ;

Hemminki, K ;

Linet, MS .

CANCER, 2004, 100 (09) :1902-1908

[9] Classification of lymphoid neoplasms: the microscope as a tool for disease discovery [J].

Jaffe, Elaine S. ;

Harris, Nancy Lee ;

Stein, Harald ;

Isaacson, Peter G. .

BLOOD, 2008, 112 (12) :4384-4399

[10] Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients:: a population-based study in Sweden [J].

Kristinsson, Sigurdur Y. ;

Bjorkholm, Magnus ;

Goldin, Lynn R. ;

McMaster, Mary L. ;

Turesson, Ingemar ;

Landgren, Ola .

BLOOD, 2008, 112 (08) :3052-3056

← 1 2 →