Tetraspanins at a glance

被引：352
作者：
Charrin, Stephanie [1 ,2 ]
Jouannet, Stephanie [1 ,2 ]
Boucheix, Claude [1 ,2 ]
Rubinstein, Eric [1 ,2 ]
机构：
[1] INSERM, U1004, F-94807 Villejuif, France
[2] Univ Paris Sud, Inst Andre Lwoff, F-94807 Villejuif, France
来源：
JOURNAL OF CELL SCIENCE | 2014年 / 127卷 / 17期
关键词：
Tetraspanin; Integrin; Membrane compartmentalization; RETINAL VASCULAR DEVELOPMENT; ENRICHED MICRODOMAINS; EXTRACELLULAR DOMAIN; INTEGRIN ALPHA-3-BETA-1; CELL-INTERACTIONS; STRUCTURAL BASIS; PROSTATE-CANCER; PLASMA-MEMBRANE; GROWTH-FACTOR; CD81; PARTNER;
D O I：
10.1242/jcs.154906
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tetraspanins are a family of proteins with four transmembrane domains that play a role in many aspects of cell biology and physiology; they are also used by several pathogens for infection and regulate cancer progression. Many tetraspanins associate specifically and directly with a limited number of proteins, and also with other tetraspanins, thereby generating a hierarchical network of interactions. Through these interactions, tetraspanins are believed to have a role in cell and membrane compartmentalization. In this Cell Science at a Glance article and the accompanying poster, we describe the basic principles underlying tetraspanin-based assemblies and highlight examples of how tetraspanins regulate the trafficking and function of their partner proteins that are required for the normal development and function of several organs, including, in humans, the eye, the kidney and the immune system.
引用
收藏
页码：3641 / 3648
页数：8
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  • [21] Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model
    Copeland, Ben T.
    Bowman, Matthew J.
    Ashman, Leonie K.
    [J]. MOLECULAR CANCER RESEARCH, 2013, 11 (01) : 95 - 105
  • [22] CD 151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin
    Crew, VK
    Burton, N
    Kagan, A
    Green, CA
    Levene, C
    Flinter, F
    Brady, RL
    Daniels, G
    Anstee, DJ
    [J]. BLOOD, 2004, 104 (08) : 2217 - 2223
  • [23] Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses
    Deng, J
    Dekruyff, RH
    Freeman, GJ
    Umetsu, DT
    Levy, S
    [J]. INTERNATIONAL IMMUNOLOGY, 2002, 14 (05) : 513 - 523
  • [24] Integrin-Associated CD151 Drives ErbB2-Evoked Mammary Tumor Onset and Metastasis
    Deng, Xinyu
    Li, Qinglin
    Hoff, John
    Novak, Marian
    Yang, Helen
    Jin, Hongyan
    Erfani, Sonia F.
    Sharma, Chandan
    Zhou, Pengcheng
    Rabinovitz, Isaac
    Sonnenberg, Arnoud
    Yi, Yajun
    Zhou, Peter
    Stipp, Christopher S.
    Kaetzel, David M.
    Hemler, Martin E.
    Yang, Xiuwei H.
    [J]. NEOPLASIA, 2012, 14 (08): : 678 - +
  • [25] The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9
    Dolores Gutierrez-Lopez, Maria
    Gilsanz, Alvaro
    Yanez-Mo, Maria
    Ovalle, Susana
    Lafuente, Esther M.
    Dominguez, Carmen
    Monk, Peter N.
    Gonzalez-Alvaro, Isidoro
    Sanchez-Madrid, Francisco
    Cabanas, Carlos
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (19) : 3275 - 3292
  • [26] TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
    Dornier, Emmanuel
    Coumailleau, Franck
    Ottavi, Jean-Francois
    Moretti, Julien
    Boucheix, Claude
    Mauduit, Philippe
    Schweisguth, Francois
    Rubinstein, Eric
    [J]. JOURNAL OF CELL BIOLOGY, 2012, 199 (03) : 481 - 496
  • [27] Early steps of the hepatitis C virus life cycle
    Dubuisson, Jean
    Helle, Francois
    Cocquerel, Laurence
    [J]. CELLULAR MICROBIOLOGY, 2008, 10 (04) : 821 - 827
  • [28] The tetraspanin CD63 enhances the internalization of the H,K-ATPase β-subunit
    Duffield, A
    Kamsteeg, EJ
    Brown, AN
    Pagel, P
    Caplan, MJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) : 15560 - 15565
  • [29] A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells
    Dunn, Cory D.
    Sulis, Maria Luisa
    Ferrando, Adolfo A.
    Greenwald, Iva
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (13) : 5907 - 5912
  • [30] Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web
    Espenel, Cedric
    Margeat, Emmanuel
    Dosset, Patrice
    Arduise, Cecile
    Le Grimellec, Christian
    Royer, Catherine A.
    Boucheix, Claude
    Rubinstein, Eric
    Milhiet, Pierre-Emmanuel
    [J]. JOURNAL OF CELL BIOLOGY, 2008, 182 (04) : 765 - 776
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