Tetraspanins at a glance

被引：369

作者：

Charrin, Stephanie ^{[1
,2
]}

Jouannet, Stephanie ^{[1
,2
]}

Boucheix, Claude ^{[1
,2
]}

Rubinstein, Eric ^{[1
,2
]}

机构：

[1] INSERM, U1004, F-94807 Villejuif, France

[2] Univ Paris Sud, Inst Andre Lwoff, F-94807 Villejuif, France

来源：

JOURNAL OF CELL SCIENCE | 2014年 / 127卷 / 17期

关键词：

Tetraspanin; Integrin; Membrane compartmentalization; RETINAL VASCULAR DEVELOPMENT; ENRICHED MICRODOMAINS; EXTRACELLULAR DOMAIN; INTEGRIN ALPHA-3-BETA-1; CELL-INTERACTIONS; STRUCTURAL BASIS; PROSTATE-CANCER; PLASMA-MEMBRANE; GROWTH-FACTOR; CD81; PARTNER;

D O I：

10.1242/jcs.154906

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tetraspanins are a family of proteins with four transmembrane domains that play a role in many aspects of cell biology and physiology; they are also used by several pathogens for infection and regulate cancer progression. Many tetraspanins associate specifically and directly with a limited number of proteins, and also with other tetraspanins, thereby generating a hierarchical network of interactions. Through these interactions, tetraspanins are believed to have a role in cell and membrane compartmentalization. In this Cell Science at a Glance article and the accompanying poster, we describe the basic principles underlying tetraspanin-based assemblies and highlight examples of how tetraspanins regulate the trafficking and function of their partner proteins that are required for the normal development and function of several organs, including, in humans, the eye, the kidney and the immune system.

引用

页码：3641 / 3648

页数：8

共 130 条

[21] Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model [J].

Copeland, Ben T. ;

Bowman, Matthew J. ;

Ashman, Leonie K. .

MOLECULAR CANCER RESEARCH, 2013, 11 (01) :95-105

[22] CD 151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin [J].

Crew, VK ;

Burton, N ;

Kagan, A ;

Green, CA ;

Levene, C ;

Flinter, F ;

Brady, RL ;

Daniels, G ;

Anstee, DJ .

BLOOD, 2004, 104 (08) :2217-2223

[23] Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses [J].

Deng, J ;

Dekruyff, RH ;

Freeman, GJ ;

Umetsu, DT ;

Levy, S .

INTERNATIONAL IMMUNOLOGY, 2002, 14 (05) :513-523

[24] Integrin-Associated CD151 Drives ErbB2-Evoked Mammary Tumor Onset and Metastasis [J].

Deng, Xinyu ;

Li, Qinglin ;

Hoff, John ;

Novak, Marian ;

Yang, Helen ;

Jin, Hongyan ;

Erfani, Sonia F. ;

Sharma, Chandan ;

Zhou, Pengcheng ;

Rabinovitz, Isaac ;

Sonnenberg, Arnoud ;

Yi, Yajun ;

Zhou, Peter ;

Stipp, Christopher S. ;

Kaetzel, David M. ;

Hemler, Martin E. ;

Yang, Xiuwei H. .

NEOPLASIA, 2012, 14 (08) :678-+

[25] The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9 [J].

Dolores Gutierrez-Lopez, Maria ;

Gilsanz, Alvaro ;

Yanez-Mo, Maria ;

Ovalle, Susana ;

Lafuente, Esther M. ;

Dominguez, Carmen ;

Monk, Peter N. ;

Gonzalez-Alvaro, Isidoro ;

Sanchez-Madrid, Francisco ;

Cabanas, Carlos .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (19) :3275-3292

[26] TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals [J].

Dornier, Emmanuel ;

Coumailleau, Franck ;

Ottavi, Jean-Francois ;

Moretti, Julien ;

Boucheix, Claude ;

Mauduit, Philippe ;

Schweisguth, Francois ;

Rubinstein, Eric .

JOURNAL OF CELL BIOLOGY, 2012, 199 (03) :481-496

[27] Early steps of the hepatitis C virus life cycle [J].

Dubuisson, Jean ;

Helle, Francois ;

Cocquerel, Laurence .

CELLULAR MICROBIOLOGY, 2008, 10 (04) :821-827

[28] The tetraspanin CD63 enhances the internalization of the H,K-ATPase β-subunit [J].

Duffield, A ;

Kamsteeg, EJ ;

Brown, AN ;

Pagel, P ;

Caplan, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :15560-15565

[29] A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells [J].

Dunn, Cory D. ;

Sulis, Maria Luisa ;

Ferrando, Adolfo A. ;

Greenwald, Iva .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (13) :5907-5912

[30] Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web [J].

Espenel, Cedric ;

Margeat, Emmanuel ;

Dosset, Patrice ;

Arduise, Cecile ;

Le Grimellec, Christian ;

Royer, Catherine A. ;

Boucheix, Claude ;

Rubinstein, Eric ;

Milhiet, Pierre-Emmanuel .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :765-776

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