Increased glycolytic substrate protection improves ischemic cardiac dysfunction and reduces injury

被引：50

作者：

Apstein, CS ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Cardiac Muscle Res Lab, Boston, MA 02118 USA

来源：

AMERICAN HEART JOURNAL | 2000年 / 139卷 / 02期

关键词：

D O I：

10.1067/mhj.2000.103920

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early clinical trials of glucose-insulin-potassium for acute myocardial infarction were inconclusive. However, several recent placebo-controlled, prospective, randomized clinical trials of glucose-insulin-potassium for acute myocardial infarction or metabolic support during and after cardiac surgery have demonstrated its efficacy. These clinical results are supported by experimental studies that have shown a strong protective effect of increased glycolytic substrate on ischemic myocardium in concert with an improved bioenergetic status.

引用

页码：S107 / S114

页数：8

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