Differences of Urinary Arsenic Metabolites and Methylation Capacity between Individuals with and without Skin Lesions in Inner Mongolia, Northern China

被引：36
|
作者：
Zhang, Qiang [1 ]
Li, Yongfang [2 ]
Liu, Juan [3 ]
Wang, Da [2 ]
Zheng, Quanmei [2 ]
Sun, Guifan [2 ]
机构：
[1] Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tianjin 300070, Peoples R China
[2] China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110001, Peoples R China
[3] Tianjin Med Univ, Lib Tianjin Med Univ, Tianjin 300070, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2014年 / 11卷 / 07期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
arsenic; groundwater; skin lesion; methylation capacity; metabolism; DRINKING-WATER; GENETIC POLYMORPHISMS; BLACKFOOT DISEASE; HUHHOT BASIN; EARLY-LIFE; EXPOSURE; BANGLADESH; TOXICITY; TAIWAN; RISK;
D O I：
10.3390/ijerph110707319
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Incomplete arsenic (As) methylation has been considered a risk factor of As-related diseases. This study aimed to examine the difference of urinary As metabolites and the methylation capacity between subjects with and without skin lesions. Urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were analyzed. The percentage of each As species (iAs%, MMA%, and DMA%), the primary methylation index (PMI) and secondary methylation index (SMI) were calculated. The results showed that subjects with skin lesions have higher levels of urinary iAs (99.08 vs. 70.63 mu g/g Cr, p = 0.006) and MMA (69.34 vs. 42.85 mu g/g Cr, p = 0.016) than subjects without skin lesions after adjustment for several confounders. Significant differences of urianry MMA% (15.49 vs. 12.11, p = 0.036) and SMI (0.74 vs. 0.81, p = 0.025) were found between the two groups. The findings of the present study suggest that subjects with skin lesions may have a lower As methylation capacity than subjects without skin lesions.
引用
收藏
页码：7319 / 7332
页数：14
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