An Updated Review of the Epigenetic Mechanism Underlying the Pathogenesis of Age-related Macular Degeneration

被引：14
作者：
Li, Xiaohua [1 ,2 ,3 ,4 ]
He, Shikun [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Zhao, Mingwei [7 ]
机构：
[1] Henan Prov Peoples Hosp, Zhengzhou, Peoples R China
[2] Henan Eye Hosp, Henan Eye Inst, Henan Key Lab Ophthalmol & Visual Sci, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Peoples Hosp, Zhengzhou, Peoples R China
[4] Henan Univ, Peoples Hosp, Zhengzhou, Peoples R China
[5] Univ Southern Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90007 USA
[6] Univ Southern Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90007 USA
[7] Peking Univ Peoples Hosp, Ophthalmol Optometry Ctr, Beijing Key Lab Diag & Therapy Retinal & Choroid, Beijing, Peoples R China
来源：
AGING AND DISEASE | 2020年 / 11卷 / 05期
关键词：
age-related macular degeneration; epigenetics; single nucleotide polymorphisms; HISTONE DEACETYLASE INHIBITORS; POLYPOIDAL CHOROIDAL VASCULOPATHY; DNA METHYLATION; POTENTIAL BIOMARKERS; INDUCED EXPRESSION; GENETIC-VARIANTS; SIRT1; RESVERATROL; HYPOXIA; TRANSCRIPTION;
D O I：
10.14336/AD.2019.1126
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Epigenetics has been recognized to play an important role in physiological and pathological processes of the human body. Accumulating evidence has indicated that epigenetic mechanisms contribute to the pathogenesis of age-related macular degeneration (AMD). Although the susceptibility related to genetic variants has been revealed by genome-wide association studies, those genetic variants may predict AMD risk only in certain human populations. Other mechanisms, particularly those involving epigenetic factors, may play an important role in the pathogenesis of AMD. Therefore, we briefly summarize the most recent reports related to such epigenetic mechanisms, including DNA methylation, histone modification, and non-coding RNA, and the interplay of genetic and epigenetic factors in the pathogenesis of AMD.
引用
收藏
页码：1219 / 1234
页数：16
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