Localized targeted antiangiogenic drug delivery for glioblastoma

被引：13
作者：
Arnone, Gregory D. [1 ]
Bhimani, Abhiraj D. [1 ]
Aguilar, Tania [1 ]
Mehta, Ankit I. [1 ]
机构：
[1] Univ Illinois, Dept Neurosurg, 912 S Wood St,4N NPI, Chicago, IL 60612 USA
来源：
JOURNAL OF NEURO-ONCOLOGY | 2018年 / 137卷 / 02期
关键词：
Glioblastoma; Glioma; VEGF; Angiogenesis; Local drug delivery; PHASE-II TRIAL; RECURRENT GLIOBLASTOMA; FOCUSED ULTRASOUND; SYSTEMIC BCNU; BRAIN; TUMOR; BEVACIZUMAB; GROWTH; MICROBUBBLES; CHEMOTHERAPY;
D O I：
10.1007/s11060-018-2747-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to treat tumors while minimizing systemic side effects. Current in-vitro and in-vivo animal studies have shown promising results that encourage the pursuit towards human clinical trials for localized antiangiogenic treatment in the near future.
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收藏
页码：223 / 231
页数：9
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