FSHR genotype affects estrogen levels but not pregnancy rates in Luxi cattle subjected to embryo transfer

被引：3
作者：
Yang, W. C. [1 ,2 ]
Li, S. J. [3 ]
Chen, L. [3 ]
Yang, L. G. [2 ]
机构：
[1] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Shaanxi, Peoples R China
[2] Huazhong Agr Univ, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan, Peoples R China
[3] Beijing Dairy Ctr, Beijing, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 01期
关键词：
Luxi cattle; Embryo transfer; FSHR; Pregnancy rates; STIMULATING-HORMONE RECEPTOR; PREMATURE OVARIAN FAILURE; MOLECULAR-BIOLOGY; GENE; COWS; POLYMORPHISMS; ASSOCIATION; IMPROVEMENT; MUTATIONS; PHENOTYPE;
D O I：
10.4238/2014.March.12.8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Follicle-stimulating hormone receptor (FSHR), which mediates the functioning of FSH, plays a central role in reproduction. We investigated bovine FSHR gene polymorphisms and analyzed their relationships with pregnancy rates after embryo transfer and with hormone concentrations on the day of embryo transfer. One reported SNP of FSHR, G-278A, located in the 5'-upstream region, was analyzed and three genotypes (GG, GA and AA) were detected in 132 Luxi cattle recipients. Statistical analysis revealed that recipients with the GG genotype had significantly higher estrogen levels on the day of embryo transfer than did GA and AA genotypes. There were no significant differences in pregnancy rates among genotypes, after embryo transfer. We conclude that variation at these loci of the FSHR gene has no significant effect on pregnancy rates in Luxi cattle.
引用
收藏
页码：1563 / 1569
页数：7
相关论文
共 27 条
[1]   Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea [J].
Achrekar, Swati K. ;
Modi, Deepak N. ;
Meherji, Pervin K. ;
Patel, Zarine M. ;
Mahale, Smita D. .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2010, 27 (06) :317-326
[2]   Falling FSH levels predict poor IVF pregnancy rates in patients whom the gonadotropins are withheld [J].
Akar, Munire Erman ;
Oktay, Kutluk .
ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2009, 280 (05) :761-765
[3]   FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey [J].
Balkan, Mahmut ;
Gedik, Abdullah ;
Akkoc, Hasan ;
Ay, Ozlem Izci ;
Erdal, M. Emin ;
Isi, Hilmi ;
Budak, Turgay .
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,
[4]   A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor [J].
Beau, I ;
Touraine, P ;
Meduri, G ;
Gougeon, A ;
Desroches, A ;
Matuchansky, C ;
Milgrom, E ;
Kuttenn, F ;
Misrahi, W .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1352-1359
[5]   Farm animal embryo technologies: Achievements and perspectives [J].
Betteridge, KJ .
THERIOGENOLOGY, 2006, 65 (05) :905-913
[6]   AVID: A global alignment program [J].
Bray, N ;
Dubchak, I ;
Pachter, L .
GENOME RESEARCH, 2003, 13 (01) :97-102
[7]   LAGAN and Multi-LAGAN: Efficient tools for large-scale multiple alignment of genomic DNA [J].
Brudno, M ;
Do, CB ;
Cooper, GM ;
Kim, MF ;
Davydov, E ;
Green, ED ;
Sidow, A ;
Batzoglou, S .
GENOME RESEARCH, 2003, 13 (04) :721-731
[8]   Polymorphism of 5' regulatory region of ovine FSHR gene and its association with litter size in Small Tail Han sheep [J].
Chu, M. X. ;
Guo, X. H. ;
Feng, C. J. ;
Li, Y. ;
Huang, D. W. ;
Feng, T. ;
Cao, G. L. ;
Fang, L. ;
Di, R. ;
Tang, Q. Q. ;
Ma, Y. H. ;
Li, K. .
MOLECULAR BIOLOGY REPORTS, 2012, 39 (04) :3721-3725
[9]   Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle [J].
Cochran, Sarah D. ;
Cole, John B. ;
Null, Daniel J. ;
Hansen, Peter J. .
BMC GENETICS, 2013, 14
[10]   Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome [J].
Conway, GS ;
Conway, E ;
Walker, C ;
Hoppner, W ;
Gromoll, J ;
Simoni, M .
CLINICAL ENDOCRINOLOGY, 1999, 51 (01) :97-99
123