No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder

被引:99
作者
Hsu, Michael C. [1 ]
Harris, Richard E. [2 ]
Sundgren, Pia C. [3 ]
Welsh, Robert C. [3 ]
Fernandes, Carlo R. [4 ]
Clauw, Daniel J. [2 ,5 ,6 ]
Williams, David A. [2 ,5 ,6 ,7 ]
机构
[1] Univ Michigan, Chron Pain & Fatigue Res Ctr, Dept Phys Med & Rehabil, Ann Arbor, MI 48106 USA
[2] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48106 USA
[3] Univ Michigan, Dept Radiol, Ann Arbor, MI 48106 USA
[4] Univ Michigan, Coll Literature Sci & Arts, Ann Arbor, MI 48106 USA
[5] Univ Michigan, Dept Med, Ann Arbor, MI 48106 USA
[6] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48106 USA
[7] Univ Michigan, Dept Psychol, Ann Arbor, MI 48106 USA
基金
美国国家卫生研究院;
关键词
Fibromyalgia; Voxel-based morphometry; MRI; Gray matter; Depression; Pain; CHRONIC WIDESPREAD PAIN; VOXEL-BASED MORPHOMETRY; CHRONIC BACK-PAIN; ABNORMALITIES; PREVALENCE; BRAIN;
D O I
10.1016/j.pain.2009.03.017
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Fibromyalgia (FM) is thought to involve abnormalities in central pain processing. Recent studies involving small samples have suggested alterations in gray matter volume (GMV) in brains of FM patients. Our objective Was to Verify these findings in a somewhat larger sample using voxel-based morphometry (VBM), while controlling for the presence of affective disorders (AD). T1-weighted magnetic resonance image (MRI) brain scans were obtained on 29 FM patients with AD, 29 FM patients without AD, and 29 age-matched healthy controls (HCs) using a 3T scanner. Segmentation, spatial normalization, and volumetric modulation were performed using an automated protocol within SPM5. Smoothed gray matter segments were entered into a voxel-wise one-way ANOVA, and a search for significant clusters was performed using thresholding methods published in previous studies (whole-brain threshold of p < .05 correcting for multiple comparisons; region-of-interest (ROI) threshold of p <= .001 uncorrected, or p < .05 small-volume corrected). The whole-brain analysis did not reveal any significant clusters. ROI-based analysis revealed a significant difference in left anterior insula GMV among the three groups (xyz = {-28, 21, 9}; p = .026, corrected). However, on post-hoc testing, FM patients without AD did not differ significantly from HC with respect to mean GMV extracted from this cluster. A significant negative correlation was found between mean cluster GMV and scores of trait anxiety (State-Trait Personality Inventory, Trait Anxiety scale: rho = -.470, p < .001). No other significant clusters were found on ROI-based analysis. Our results emphasize the importance of correcting for AD when carrying out VBM studies in chronic pain. (C) 2009 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:262 / 267
页数:6
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