Cyclodextrins in non-viral gene delivery

被引：107
作者：
Lai, Wing-Fu [1 ]
机构：
[1] Yonsei Univ, Coll Dent, Dept Oral Biol, Div Anat & Dev Biol, Seoul 120749, South Korea
来源：
BIOMATERIALS | 2014年 / 35卷 / 01期
关键词：
Cyclodextrin; Gene delivery; Non-viral vector; Polymer; Transfection; NUCLEIC-ACID DELIVERY; BETA-CYCLODEXTRIN; ALPHA-CYCLODEXTRIN; IN-VIVO; POLYAMIDOAMINE DENDRIMER; OLIGONUCLEOTIDE DELIVERY; PLASMID DNA; PHARMACEUTICAL APPLICATIONS; ABSORPTION ENHANCER; CONTAINING POLYMERS;
D O I：
10.1016/j.biomaterials.2013.09.061
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. They consist of (alpha-1,4)-linked glucose units, and possess a basket-shaped topology with an "inner-outer" amphiphilic character. Over the years, substantial efforts have been undertaken to investigate the possible use of CDs in drug delivery and controlled drug release, yet the potential of CDs in gene delivery has received comparatively less discussion in the literature. In this article, we will first discuss the properties of CDs for gene delivery, followed by a synopsis of the use of CDs in development and modification of non-viral gene carriers. Finally, areas that are noteworthy in CD-based gene delivery will be highlighted for future research. Due to the application prospects of CDs, it is anticipated that CDs will continue to emerge as an important tool for vector development, and will play significant roles in facilitating non-viral gene delivery in the forthcoming decades. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：401 / 411
页数：11
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