Physical Activity, Physical Fitness, and Leukocyte Telomere Length: The Cardiovascular Health Study

被引:35
|
作者
Soares-Miranda, Luisa [1 ]
Imamura, Fumiaki [2 ]
Siscovick, David [3 ,4 ]
Jenny, Nancy Swords [5 ]
Fitzpatrick, Annette L. [4 ]
Mozaffarian, Dariush [6 ]
机构
[1] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure, P-4200450 Oporto, Portugal
[2] Univ Cambridge, Sch Clin Med, Inst Metab Sci, Epidemiol Unit,MRC, Cambridge, England
[3] New York Acad Med, New York, NY USA
[4] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[5] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA
[6] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
来源
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE | 2015年 / 47卷 / 12期
基金
英国医学研究理事会;
关键词
BIOLOGIC AGING; DNA; ELDERLY; EXERCISE; FITNESS; LIFE-STYLE; SEDENTARY BEHAVIOR; LEISURE-TIME; DNA-DAMAGE; EXERCISE; DISEASE; ASSOCIATION; MORTALITY; HALLMARKS; OUTCOMES;
D O I
10.1249/MSS.0000000000000720
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Introduction The influence of physical activity (PA) and physical fitness (PF) at older ages on changes in telomere length (TL)repetitive DNA sequences that may mark biologic agingis not well-established. Few prior studies (mainly cross-sectional) have been conducted in older adults, and few studies have evaluated PF. Methods We investigated cross-sectional and prospective associations of PA and PF with leukocyte TL among 582 older adults (mean SD age, 73 5 yr at baseline) in the Cardiovascular Health Study, with serial TL measures and PA and PF assessed multiple times. Cross-sectional associations were assessed using multivariable repeated-measures regression, in which cumulatively averaged PA and PF measures were related to TL. Longitudinal analyses assessed cumulatively averaged PA and PF against later changes in TL, and changes in cumulatively averaged PA and PF against changes in TL. Results Cross-sectionally, greater walking distance and chair test performance, but not other PA and PF measures, were each associated with longer TL (P trend = 0.007 and 0.04, respectively). In longitudinal analyses, no significant associations of baseline PA and PF with change in TL were observed. In contrast, changes in leisure-time activity and chair test performance were each inversely associated with changes in TL. Conclusions Cross-sectional analyses suggest that greater PA and PF are associated with longer TL. Prospective analyses show that changes in PA and PF are associated with differences in changes in TL. Even later in life, changes in certain PA and PF measures are associated with changes in TL, suggesting that leisure-time activity and fitness could reduce leukocyte telomere attrition among older adults.
引用
收藏
页码:2525 / 2534
页数:10
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