Eliminating latent tuberculosis

被引：169

作者：

Young, Douglas B. ^{[1
,2
]}

Gideon, Hannah P. ^{[3
]}

Wilkinson, Robert J. ^{[1
,3
,4
]}

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

[2] Univ London Imperial Coll Sci Technol & Med, Div Investigat Sci, London SW7 2AZ, England

[3] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

[4] Univ London Imperial Coll Sci Technol & Med, Div Med, London W2 1PG, England

来源：

TRENDS IN MICROBIOLOGY | 2009年 / 17卷 / 05期

基金：

英国惠康基金;

关键词：

TUMOR-NECROSIS-FACTOR; HEALTH-CARE WORKERS; T-CELL RESPONSES; MYCOBACTERIUM-TUBERCULOSIS; HYPOXIC RESPONSE; IMMUNE RECONSTITUTION; TUBERCLE-BACILLI; ALPHA-CRYSTALLIN; DORMANCY REGULON; LUNG-TISSUE;

D O I：

10.1016/j.tim.2009.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tuberculosis is recognized as the world's leading bacterial cause of death. Yet 95% of infection is believed to exist in an asymptomatic 'latent' form that is defined not by the identification of bacteria, but by the host immune response in the form of reactivity to tuberculosis proteins in the tuberculin skin test. It seems likely that clinically defined latent tuberculosis actually represents a spectrum that runs from elimination of live bacilli to subclinical disease: hence, it might be unhelpful to use a single term to describe all these conditions. To support this view, here we focus on recent increased understanding of the heterogeneity in both bacillary physiology and host immune response that potentially illuminates new therapeutic and diagnostic approaches to this condition.

引用

页码：183 / 188

页数：6

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