Emerging Systemic Therapies for Colorectal Cancer

被引：29
|
作者：
Veenstra, Christine M. [1 ]
Krauss, John C. [1 ]
机构：
[1] Univ Michigan, Dept Internal Med, Div Hematol Oncol, 300 North Ingalls,Room 3A22, Ann Arbor, MI 48109 USA
来源：
CLINICS IN COLON AND RECTAL SURGERY | 2018年 / 31卷 / 03期
关键词：
colorectal cancer; emerging therapies; targeted therapy; immunotherapy; clinical trials; MIGRATION-INHIBITORY FACTOR; III COLON-CANCER; SURGICAL ADJUVANT BREAST; ENGINEERED T-CELLS; OPEN-LABEL; MONOCLONAL-ANTIBODY; IMPROVED SURVIVAL; PLUS BEVACIZUMAB; LIVER METASTASIS; RANDOMIZED-TRIAL;
D O I：
10.1055/s-0037-1602238
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Despite advances over the past 20 years in colorectal cancer (CRC) screening, diagnosis, and treatment, survival outcomes remain suboptimal. Five-year survival for patients with locally advanced CRC is 69%; 5-year survival drops to 12% for patients with metastatic disease. Novel, effective systemic therapies are needed to improve long-term outcomes. In this review, we describe currently available systemic therapies for the treatment of locally advanced and metastatic CRC and discuss emerging therapies, including encouraging advances in identifying novel targeted agents and exciting responses to immunotherapeutic agents.
引用
收藏
页码：179 / 191
页数：13
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