Long-term follow-up in children with benign convulsions associated with gastroenteritis

被引：35

作者：

Verrotti, Alberto ^{[1
]}

Moavero, Romina ^{[2
]}

Vigevano, Federico ^{[3
]}

Cantonetti, Laura ^{[3
]}

Guerra, Azzurra ^{[4
]}

Spezia, Elisabetta ^{[4
]}

Tricarico, Antonella ^{[4
]}

Nanni, Giuliana ^{[5
]}

Agostinelli, Sergio ^{[5
]}

Chiarelli, Francesco ^{[5
]}

Parisi, Pasquale ^{[6
]}

Capovilla, Giuseppe ^{[7
]}

Beccaria, Francesca ^{[7
]}

Spalice, Alberto ^{[8
]}

Coppola, Giangennaro ^{[9
]}

Franzoni, Emilio ^{[10
]}

Gentile, Valentina ^{[10
]}

Casellato, Susanna ^{[11
]}

Veggiotti, Pierangelo ^{[12
]}

Malgesini, Sara ^{[12
]}

Crichiutti, Giovanni ^{[13
]}

Balestri, Paolo ^{[14
]}

Grosso, Salvatore ^{[14
]}

Zamponi, Nelia ^{[15
]}

Incorpora, Gemma ^{[16
]}

Savasta, Salvatore ^{[17
]}

Costa, Paola ^{[18
]}

Pruna, Dario ^{[19
]}

Cusmai, Raffaella ^{[3
]}

机构：

[1] Univ Perugia, Dept Pediat, I-06100 Perugia, Italy

[2] Tor Vergata Univ Hosp Rome, Child Neurol Unit, Syst Med Dept, Rome, Italy

[3] Bambino Gesu Pediat Hosp, IRCCS, Pediat Neurol Unit, Dept Neurosci, Rome, Italy

[4] Azienda Policlin Modena, Modena, Italy

[5] Univ G dAnnunzio, Dept Pediat, Chieti, Italy

[6] Univ Roma La Sapienza, Fac Med 2, Chair Pediat, I-00185 Rome, Italy

[7] C Poma Hosp, Dept Child Neuropsychiat, Epilepsy Ctr, Mantua, Italy

[8] Univ Roma La Sapienza, Dept Pediat, Rome, Italy

[9] Univ Salerno, Dept Child Neuropsychiat, I-84100 Salerno, Italy

[10] Univ Bologna, Dept Child Neuropsychiat, Bologna, Italy

[11] Univ Sassari, Dept Child Neuropsychiat, I-07100 Sassari, Italy

[12] Fdn C Mondino Inst Neurol, Child EEG Unit, Dept Child Neuropsychiat, Pavia, Italy

[13] Univ Udine, DPMSC, Dept Pediat, I-33100 Udine, Italy

[14] Univ Siena, Dept Pediat, I-53100 Siena, Italy

[15] Univ Ancona, Dept Child Neuropsychiat, I-60128 Ancona, Italy

[16] Hosp Ragusa, Dept Pediat, Ragusa, Italy

[17] Univ Pavia, Dept Pediat, I-27100 Pavia, Italy

[18] IRCCS Burlo Garofalo, Dept Child Neuropsychiat, Trieste, Italy

[19] Azienda Osped Univ Cagliari, Div Child Neurol & Psychiat, Cagliari, Italy

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2014年 / 18卷 / 05期

关键词：

Seizures; Gastroenteritis; Anti-epileptic drugs; Long-term follow-up; Seizure relapse; FAMILIAL INFANTILE EPILEPSY; MILD GASTROENTERITIS; ROTAVIRUS GASTROENTERITIS; AFEBRILE SEIZURES; CHOREOATHETOSIS SYNDROME; PHENOTYPIC SPECTRUM; PRRT2; MUTATIONS; ICTAL EEG; INFANCY; CHILDHOOD;

D O I：

10.1016/j.ejpn.2014.04.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The outcome of benign convulsions associated with gastroenteritis (CwG) has generally been reported as being excellent. However, these data need to be confirmed in studies with longer follow-up evaluations. Aim: To assess the long-term neurological outcome of a large sample of children presenting with CwG. Methods: We reviewed clinical features of 81 subjects presenting with CwG (1994-2010) from three different Italian centers with a follow-up period of at least 3 years. Results: Follow-up period ranged from 39 months to 15 years (mean 9.8 years). Neurological examination and cognitive level at the last evaluation were normal in all the patients. A mild attention deficit was detected in three cases (3.7%). Fourteen children (17.3%) received chronic anti-epileptic therapy. Interictal EEG abnormalities detected at onset in 20 patients (24.7%) reverted to normal. Transient EEG epileptiform abnormalities were detected in other three cases (3.7%), and a transient photosensitivity in one (1.2%). No recurrence of CwG was observed. Three patients (3.7%) presented with a febrile seizure and two (2.5%) with an unprovoked seizure, but none developed epilepsy. Conclusions: The long-term evaluation of children with CwG confirms the excellent prognosis of this condition, with normal psychomotor development and low risk of relapse and of subsequent epilepsy. (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：572 / 577

页数：6

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