Meta-analyses between 18 candidate genetic markers and overweight/obesity

被引：13
作者：
Tang, Linlin [1 ]
Ye, Huadan [1 ]
Hong, Qingxiao [1 ]
Chen, Fei [1 ]
Wang, Qinwen [1 ,3 ]
Xu, Leiting [1 ,3 ]
Bu, Shizhong [1 ,3 ]
Liu, Qiong [1 ,3 ]
Ye, Meng [2 ]
Wang, Dao Wen [4 ,5 ]
Mai, Yifeng [2 ]
Duan, Shiwei [1 ,3 ]
机构：
[1] Ningbo Univ, Sch Med, Zhejiang Prov Key Lab Pathophysiol, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Affiliated Hosp, Ningbo 315000, Zhejiang, Peoples R China
[3] Ningbo Univ, Sch Med, Ctr Diabet, Ningbo 315211, Zhejiang, Peoples R China
[4] Huazhong Univ Sci & Technol, Inst Hypertens, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China
[5] Huazhong Univ Sci & Technol, Dept Internal Med, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China
来源：
DIAGNOSTIC PATHOLOGY | 2014年 / 9卷
基金：
中国国家自然科学基金;
关键词：
SH2B1; FAIM2; Polymorphism; Overweight; Obesity; Meta-analysis; PLASMINOGEN-ACTIVATOR INHIBITOR-1; STEROID-INDUCED OSTEONECROSIS; ESTER TRANSFER PROTEIN; BODY-MASS INDEX; ADIPOSE-TISSUE; ADRENERGIC-RECEPTOR; LIPID-METABOLISM; APOLIPOPROTEIN-E; ENERGY-BALANCE; FEMORAL-HEAD;
D O I：
10.1186/1746-1596-9-56
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aims: The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity. Methods: A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0. Results: Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.09-1.34, P = 0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR = 1.11, 95% CI = 1.01-1.22, P = 0.04). Conclusion: Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity.
引用
收藏
页数：12
相关论文
共 59 条
[1]   Effect of ultrasound therapy on the repair of Gastrocnemius muscle injury in rats [J].
Balejo Piedade, Maria Cristina ;
Galhardo, Milene Sanches ;
Battlehner, Claudia Naves ;
Ferreira, Marcelo Alves ;
Caldini, Elia Garcia ;
Szymanski de Toledo, Olga Maria .
ULTRASONICS, 2008, 48 (05) :403-411
[2]   Brown adipose tissue: Function and physiological significance [J].
Cannon, B ;
Nedergaard, J .
PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :277-359
[3]   Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors [J].
Chapman, M. John ;
Le Goff, Wilfried ;
Guerin, Maryse ;
Kontush, Anatol .
EUROPEAN HEART JOURNAL, 2010, 31 (02) :149-164
[4]   Elderly women: Homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism) [J].
Chmurzynska, Agata ;
Malinowska, Anna M. ;
Twardowska-Rajewska, Jolanta ;
Gawecki, Jan .
NUTRITION, 2013, 29 (06) :841-844
[5]   Mitochondrial uncoupling as a target in the treatment of obesity [J].
Costford, Sheila ;
Gowing, Adrienne ;
Harper, Mary-Ellen .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2007, 10 (06) :671-678
[6]   Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides [J].
Cravatt, BF ;
Giang, DK ;
Mayfield, SP ;
Boger, DL ;
Lerner, RA ;
Gilula, NB .
NATURE, 1996, 384 (6604) :83-87
[7]   Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes [J].
Dalgaard, LT ;
Pedersen, O .
DIABETOLOGIA, 2001, 44 (08) :946-965
[8]   Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis [J].
de Matos, Leandro Luongo ;
Del Giglio, Adriana Braz ;
Matsubayashi, Carolina Ogawa ;
Farah, Michelle de Lima ;
Del Giglio, Auro ;
da Silva Pinhal, Maria Aparecida .
DIAGNOSTIC PATHOLOGY, 2012, 7
[9]   Endocannabinoid control of food intake and energy balance [J].
Di Marzo, V ;
Matias, I .
NATURE NEUROSCIENCE, 2005, 8 (05) :585-589
[10]   Association between obesity and a polymorphism in the β1-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women [J].
Dionne, IJ ;
Garant, MJ ;
Nolan, AA ;
Pollin, TI ;
Lewis, DG ;
Shuldiner, AR ;
Poehlman, ET .
INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (05) :633-639
123456