Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications

被引：57

作者：

Seli, Emre ^{[1
]}

Babayev, Elnur ^{[1
]}

Collins, Stephen C. ^{[1
]}

Nemeth, Gabor ^{[2
]}

Horvath, Tamas L. ^{[1
,2
,3
,4
]}

机构：

[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA

[2] Univ Szeged, Fac Med, Dept Obstet & Gynecol, H-6701 Szeged, Hungary

[3] Yale Univ, Sch Med, Dept Comparat Med, New Haven, CT 06520 USA

[4] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA

来源：

MOLECULAR ENDOCRINOLOGY | 2014年 / 28卷 / 06期

基金：

美国国家卫生研究院;

关键词：

AGOUTI-RELATED PROTEIN; AMINO-ACID TURNOVER; BODY-MASS INDEX; OOCYTE DEVELOPMENTAL COMPETENCE; HYPOTHALAMIC ARCUATE NUCLEUS; GROWTH-DIFFERENTIATION FACTOR-9; GRANULOSA-CELL APOPTOSIS; LEPTIN-DEFICIENT MICE; DIET-INDUCED OBESITY; LIVE BIRTH-RATES;

D O I：

10.1210/me.2013-1413

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Female fertility is highly dependent on successful regulation of energy metabolism. Central processes in the hypothalamus monitor the metabolic state of the organism and, together with metabolic hormones, drive the peripheral availability of energy for cellular functions. In the ovary, the oocyte and neighboring somatic cells of the follicle work in unison to achieve successful metabolism of carbohydrates, amino acids, and lipids. Metabolic disturbances such as anorexia nervosa, obesity, and diabetes mellitus have clinically important consequences on human reproduction. In this article, we review the metabolic determinants of female reproduction and their role in infertility.

引用

页码：790 / 804

页数：15

共 184 条

[51] Fatty Acid Oxidation and Meiotic Resumption in Mouse Oocytes [J].

Downs, Stephen M. ;

Mosey, Jessica L. ;

Klinger, Jonathan .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 2009, 76 (09) :844-853

[52] Pregnancy outcomes of women with and without a history of anorexia nervosa [J].

Eagles, J. M. ;

Lee, A. J. ;

Raja, E. Amalraj ;

Millar, H. R. ;

Bhattacharya, S. .

PSYCHOLOGICAL MEDICINE, 2012, 42 (12) :2651-2660

[53] Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area [J].

Elias, CF ;

Aschkenasi, C ;

Lee, C ;

Kelly, J ;

Ahima, RS ;

Bjorbæk, C ;

Flier, JS ;

Saper, CB ;

Elmquist, JK .

NEURON, 1999, 23 (04) :775-786

[54] AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations [J].

Eng, Grace S. ;

Sheridan, Rachael A. ;

Wyman, Amanda ;

Chi, Maggie M. -Y. ;

Bibee, Kristin P. ;

Jungheim, Emily S. ;

Moley, Kelle H. .

DIABETES, 2007, 56 (09) :2228-2234

[55] Mouse oocytes regulate metabolic cooperativity between granulosa cells and oocytes: Amino acid transport [J].

Eppig, JJ ;

Pendola, FL ;

Wigglesworth, K ;

Pendola, JK .

BIOLOGY OF REPRODUCTION, 2005, 73 (02) :351-357

[56] INTERCOMMUNICATION BETWEEN MAMMALIAN OOCYTES AND COMPANION SOMATIC-CELLS [J].

EPPIG, JJ .

BIOESSAYS, 1991, 13 (11) :569-574

[57] Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y [J].

Erickson, JC ;

Clegg, KE ;

Palmiter, RD .

NATURE, 1996, 381 (6581) :415-418

[58] Impact of isolated obesity on ICSI outcome [J].

Esinler, I. ;

Bozdag, G. ;

Yarali, H. .

REPRODUCTIVE BIOMEDICINE ONLINE, 2008, 17 (04) :583-587

[59] Cholesterol metabolism and embryogenesis [J].

Farese, RV ;

Herz, J .

TRENDS IN GENETICS, 1998, 14 (03) :115-120

[60]

Ferguson EM, 1999, J REPROD FERTIL, V116, P373, DOI 10.1530/jrf.0.1160373

← 1 2 3 4 5 6 7 8 9 10 →