Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice

被引：18

作者：

Hirakata, Saki ^{[1
]}

Aoki, Hiroki ^{[2
]}

Ohno-Urabe, Satoko ^{[1
]}

Nishihara, Michihide ^{[1
]}

Furusho, Aya ^{[1
]}

Nishida, Norifumi ^{[1
]}

Ito, Sohei ^{[1
]}

Hayashi, Makiko ^{[1
]}

Yasukawa, Hideo ^{[1
]}

Imaizumi, Tsutomu ^{[3
]}

Hiromatsu, Sinichi ^{[4
]}

Tanaka, Hiroyuki ^{[4
]}

Fukumoto, Yoshihiro ^{[1
]}

机构：

[1] Kurume Univ, Dept Internal Med, Div Cardiovasc Med, Sch Med, Kurume, Fukuoka, Japan

[2] Kurume Univ, Cardiovasc Res Inst, 67 Asahimachi, Kurume, Fukuoka 8300011, Japan

[3] Int Univ Hlth & Welf, Fukuoka, Japan

[4] Kurume Univ, Dept Surg, Div Cardiovasc Surg, Sch Med, Kurume, Fukuoka, Japan

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2020年 / 5卷 / 02期

关键词：

aortic dissection; inflammation; Jak/Stat; smooth muscle cells; INTERNATIONAL REGISTRY; ANGIOTENSIN-II; TENASCIN-C; EXPRESSION; PROLIFERATION; INFLAMMATION; FIBROBLAST; ANEURYSMS; INSIGHTS;

D O I：

10.1016/j.jacbts.2019.10.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aortic dissection (AD) is the acute destruction of aortic wall and is reportedly induced by inflammatory response. Here we investigated the role of smooth muscle Socs3 (a negative regulator of Janus kinases/signal transducer and activator of transcription signaling) in AD pathogenesis using a mouse model generated via beta-aminopropionitrile and angiotensin II infusion. Socs3 deletion specifically in smooth muscle cells yielded a chronic inflammatory response of the aortic wall, which was associated with increased fibroblasts, reinforced aortic tensile strength, and less-severe tissue destruction. Although an acute inflammatory response is detrimental in AD, smooth muscle-regulated inflammatory response seemed protective against AD. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：126 / 144

页数：19

共 44 条

[1] Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture [J].

Anzai, Atsushi ;

Shimoda, Masayuki ;

Endo, Jin ;

Kohno, Takashi ;

Katsumata, Yoshinori ;

Matsuhashi, Tomohiro ;

Yamamoto, Tsunehisa ;

Ito, Kentaro ;

Yan, Xiaoxiang ;

Shirakawa, Kosuke ;

Shimizu-Hirota, Ryoko ;

Yamada, Yoshitake ;

Ueha, Satoshi ;

Shinmura, Ken ;

Okada, Yasunori ;

Fukuda, Keiichi ;

Sano, Motoaki .

CIRCULATION RESEARCH, 2015, 116 (04) :612-623

[2] Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin β6 [J].

Azare, Janeen ;

Leslie, Kenneth ;

Al-Ahmadie, Hikmat ;

Gerald, William ;

Weinreb, Paul H. ;

Violette, Shelia M. ;

Bromberg, Jacqueline .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (12) :4444-4453

[3] Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation [J].

Banes-Berceli, Amy K. L. ;

Ketsawatsomkron, Pimonrat ;

Ogbi, Safia ;

Patel, Bela ;

Pollock, David M. ;

Marrero, Mario B. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (02) :H1291-H1299

[4] Collagen is reduced and disrupted in human aneurysms and dissections of ascending aorta [J].

Borges, Luciano de Figueiredo ;

Jaldin, Rodrigo Gibin ;

Dias, Ricardo Ribeiro ;

Groppo Stolf, Noedir Antonio ;

Michel, Jean-Baptiste ;

Gutierrez, Paulo Sampaio .

HUMAN PATHOLOGY, 2008, 39 (03) :437-443

[5]

Brownstein Adam J, 2017, Aorta (Stamford), V5, P11, DOI 10.12945/j.aorta.2017.17.003

[6] Peroxiredoxin 5 Protects TGF-βInduced Fibrosis by Inhibiting Stat3 Activation in Rat Kidney Interstitial Fibroblast Cells [J].

Choi, Hoon-In ;

Ma, Seong Kwon ;

Bae, Eun Hui ;

Lee, JongUn ;

Kim, Soo Wan .

PLOS ONE, 2016, 11 (02)

[7] THE DIAGNOSIS AND MANAGEMENT OF AORTIC DISSECTION [J].

CRAWFORD, ES .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 264 (19) :2537-2541

[8] Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration [J].

Das, Amitava ;

Sinha, Mithun ;

Datta, Soma ;

Abas, Motaz ;

Chaffee, Scott ;

Sen, Chandan K. ;

Roy, Sashwati .

AMERICAN JOURNAL OF PATHOLOGY, 2015, 185 (10) :2596-2606

[9]

DAVID Bioinformatics Database, DAVID BIOINF RES 6 8

[10] Wnt4/β-Catenin Signaling in Medullary Kidney Myofibroblasts [J].

DiRocco, Derek P. ;

Kobayashi, Akio ;

Taketo, Makoto M. ;

McMahon, Andrew P. ;

Humphreys, Benjamin D. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 24 (09) :1399-1412

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