Measuring and mapping the global burden of antimicrobial resistance

被引：145

作者：

Hay, Simon I. ^{[1
,2
]}

Rao, Puja C. ^{[1
]}

Dolecek, Christiane ^{[3
,4
]}

Day, Nicholas P. J. ^{[3
,4
]}

Stergachis, Andy ^{[5
]}

Lopez, Alan D. ^{[2
,6
]}

Murray, Christopher J. L. ^{[1
]}

机构：

[1] Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave, Seattle, WA 98121 USA

[2] Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Old Rd Campus, Oxford OX3 7LF, England

[3] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Old Rd Campus,Roosevelt Dr, Oxford OX3 7FZ, England

[4] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, 420-6 Rajvithi Rd, Bangkok 10400, Thailand

[5] Univ Washington, Sch Pharm, H-362B Box 357631, Seattle, WA 98195 USA

[6] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Level 5,207 Bouverie St, Carlton, Vic 3053, Australia

来源：

BMC MEDICINE | 2018年 / 16卷

基金：

英国惠康基金;

关键词：

Antimicrobial resistance; Drug-resistant infections; Microbial; Anti-infective agents; Antimicrobial drugs; Global health; Global burden of disease; Public health;

D O I：

10.1186/s12916-018-1073-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The increasing number and global distribution of pathogens resistant to antimicrobial drugs is potentially one of the greatest threats to global health, leading to health crises arising from infections that were once easy to treat. Infections resistant to antimicrobial treatment frequently result in longer hospital stays, higher medical costs, and increased mortality. Despite the long-standing recognition of antimicrobial resistance (AMR) across many settings, there is surprisingly poor information about its geographical distribution over time and trends in its population prevalence and incidence. This makes reliable assessments of the health burden attributable to AMR difficult, weakening the evidence base to drive forward research and policy agendas to combat AMR. The inclusion of mortality and morbidity data related to drug-resistant infections into the annual Global Burden of Disease Study should help fill this policy void.

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