Epidemiology and clinical characteristics of GERD in the Japanese population

被引:280
作者
Fujiwara, Yasuhiro [1 ]
Arakawa, Tetsuo [1 ]
机构
[1] Osaka City Univ, Dept Gastroenterol, Grad Sch Med, Abeno Ku, Osaka 5458585, Japan
关键词
Gastroesophageal reflux disease; Epidemiology; Non-erosive reflux disease; Hiatal hernia; Gastric atrophy; GASTROESOPHAGEAL-REFLUX DISEASE; HELICOBACTER-PYLORI INFECTION; LOS-ANGELES CLASSIFICATION; GASTRIC-MUCOSAL ATROPHY; PROTON-PUMP INHIBITOR; PEPTIC-ULCER DISEASE; DIABETIC-PATIENTS; ACID-SECRETION; HIATUS-HERNIA; INTEROBSERVER AGREEMENT;
D O I
10.1007/s00535-009-0047-5
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons for the increase in the prevalence of GERD may be due to increases in gastric acid secretion, a decrease in the Helicobacter pylori infection rate, more attention being paid to GERD, and advances in the concept of GERD. More than half of GERD patients had non-erosive reflux disease, and the majority (87%) of erosive esophagitis was mild type, such as Los Angeles classification grade A and grade B. There were several identified risk factors, such as older age, obesity, and hiatal hernia. In particular, mild gastric atrophy and absence of H. pylori infection influence the characteristics of GERD in the Japanese population. We also discuss GERD in the elderly; asymptomatic GERD; the natural history of GERD; and associations between GERD and peptic ulcer disease and H. pylori eradication. We examined the prevalence of GERD in patients with specific diseases, and found a higher prevalence of GERD, compared with that in the general population, in patients with diabetes mellitus, those with obstructive sleep apnea syndrome, and those with bronchial asthma. We provide a comprehensive review of GERD in the Japanese population and raise several clinical issues.
引用
收藏
页码:518 / 534
页数:17
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